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ARSA2_AQUAE
ID   ARSA2_AQUAE             Reviewed;         299 AA.
AC   O66674;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Putative arsenical pump-driving ATPase 2;
DE            EC=7.3.2.7;
DE   AltName: Full=Arsenical resistance ATPase 2;
DE   AltName: Full=Arsenite-translocating ATPase 2;
DE   AltName: Full=Arsenite-transporting ATPase 2;
GN   Name=arsA2; OrderedLocusNames=aq_343;
OS   Aquifex aeolicus (strain VF5).
OC   Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
OX   NCBI_TaxID=224324;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=VF5;
RX   PubMed=9537320; DOI=10.1038/32831;
RA   Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L.,
RA   Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R.,
RA   Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
RT   "The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
RL   Nature 392:353-358(1998).
CC   -!- FUNCTION: Anion-transporting ATPase. Catalyzes the extrusion of
CC       arsenite (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:11348, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29242, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.3.2.7;
CC   -!- SIMILARITY: Belongs to the arsA ATPase family. {ECO:0000305}.
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DR   EMBL; AE000657; AAC06625.1; -; Genomic_DNA.
DR   PIR; F70330; F70330.
DR   RefSeq; NP_213234.1; NC_000918.1.
DR   RefSeq; WP_010880172.1; NC_000918.1.
DR   AlphaFoldDB; O66674; -.
DR   SMR; O66674; -.
DR   STRING; 224324.aq_343; -.
DR   EnsemblBacteria; AAC06625; AAC06625; aq_343.
DR   KEGG; aae:aq_343; -.
DR   PATRIC; fig|224324.8.peg.277; -.
DR   eggNOG; COG0003; Bacteria.
DR   HOGENOM; CLU_040761_4_0_0; -.
DR   InParanoid; O66674; -.
DR   OMA; QFMEAPE; -.
DR   OrthoDB; 1225869at2; -.
DR   Proteomes; UP000000798; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0015446; F:ATPase-coupled arsenite transmembrane transporter activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR025723; Anion-transp_ATPase-like_dom.
DR   InterPro; IPR016300; ATPase_ArsA/GET3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10803; PTHR10803; 1.
DR   Pfam; PF02374; ArsA_ATPase; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00345; GET3_arsA_TRC40; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance; ATP-binding; Nucleotide-binding; Reference proteome;
KW   Translocase.
FT   CHAIN           1..299
FT                   /note="Putative arsenical pump-driving ATPase 2"
FT                   /id="PRO_0000152261"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   299 AA;  34559 MW;  24E70DD8A6A25A42 CRC64;
     MRVFFFGGKG GVGKTTASSA FAVKLSEQGK KVLLLSTDPA HSLSDVFNTE LQGETKLSEN
     LTVKEIDLNE ELKEYRSRVF KLAEATLRKE TLRELEGIIH SLEESPGIED VVIFEALSKE
     VVYRENEYDY IVVDTAPTGH TLGLLKTVRN LGNFLEEIVK LKEKVYELKK LSGKSVHEEA
     LEYLKERKER FKKFSEIIYD KSYFFAVLTP EKLPFEETKR LVNSLKHYGI RVKALIINKV
     LPENPQDEFL KARKEVEKKF LKEIENYFMD IEKISIPYQK EEVVGYEKLK EFSKFLPLG
 
 
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