ID   ARSA_CHLTE              Reviewed;         405 AA.
AC   Q46366;
DT   27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2002, sequence version 2.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=Putative arsenical pump-driving ATPase;
DE            EC=7.3.2.7;
DE   AltName: Full=Arsenical resistance ATPase;
DE   AltName: Full=Arsenite-translocating ATPase;
DE   AltName: Full=Arsenite-transporting ATPase;
GN   OrderedLocusNames=CT1945;
OS   Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS)
OS   (Chlorobium tepidum).
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae; Chlorobaculum.
OX   NCBI_TaxID=194439;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49652 / DSM 12025 / NBRC 103806 / TLS;
RX   PubMed=12093901; DOI=10.1073/pnas.132181499;
RA   Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J.,
RA   DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D.,
RA   Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M.,
RA   Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V.,
RA   Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M.,
RA   White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A.,
RA   Fraser C.M.;
RT   "The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic,
RT   anaerobic, green-sulfur bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-405.
RA   Chung S., Frank G., Zuber H., Bryant D.A.;
RT   "Genes encoding two chlorosome components from the green sulfur bacteria
RT   Chlorobium vibrioforme strain 8327D and Chlorobium tepidum.";
RL   Photosyn. Res. 41:261-275(1994).
CC   -!- FUNCTION: Anion-transporting ATPase. Catalyzes the extrusion of
CC       arsenite (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:11348, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29242, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.3.2.7;
CC   -!- SIMILARITY: Belongs to the arsA ATPase family. {ECO:0000305}.
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DR   EMBL; AE006470; AAM73164.1; -; Genomic_DNA.
DR   EMBL; U09866; AAA18790.1; -; Unassigned_DNA.
DR   RefSeq; NP_662822.1; NC_002932.3.
DR   RefSeq; WP_010933602.1; NC_002932.3.
DR   AlphaFoldDB; Q46366; -.
DR   SMR; Q46366; -.
DR   STRING; 194439.CT1945; -.
DR   PRIDE; Q46366; -.
DR   DNASU; 1008253; -.
DR   EnsemblBacteria; AAM73164; AAM73164; CT1945.
DR   KEGG; cte:CT1945; -.
DR   PATRIC; fig|194439.7.peg.1762; -.
DR   eggNOG; COG0003; Bacteria.
DR   HOGENOM; CLU_040761_1_0_10; -.
DR   OMA; YIPPEDA; -.
DR   OrthoDB; 1225869at2; -.
DR   Proteomes; UP000001007; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0015446; F:ATPase-coupled arsenite transmembrane transporter activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.60.40.790; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR025723; Anion-transp_ATPase-like_dom.
DR   InterPro; IPR040612; ArsA_HSP20-like.
DR   InterPro; IPR016300; ATPase_ArsA/GET3.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10803; PTHR10803; 1.
DR   Pfam; PF02374; ArsA_ATPase; 1.
DR   Pfam; PF17886; ArsA_HSP20; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00345; GET3_arsA_TRC40; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance; ATP-binding; Nucleotide-binding; Reference proteome;
KW   Translocase.
FT   CHAIN           1..405
FT                   /note="Putative arsenical pump-driving ATPase"
FT                   /id="PRO_0000152262"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        374
FT                   /note="P -> A (in Ref. 2; AAA18790)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   405 AA;  45848 MW;  5CD79FA866E0890E CRC64;
     MRILTFTGKG GVGKTSVSAA TAVRLSEMGH RTLVLSTDPA HSLSDSFNIQ LGAEPTKIKE
     NLHAIEVNPY VDLKQNWHSV QKYYTRIFMA QGVSGVMADE MTILPGMEEL FSLLRIKRYK
     SAGLYDALVL DTAPTGETLR LLSLPDTLSW GMKAVKNVNK YIVRPLSKPL SKMSDKIAYY
     IPPEDAIESV DQVFDELEDI REILTDNVKS TVRLVMNAEK MSIKETMRAL TYLNLYGFKV
     DMVLVNKLLD AQENSGYLEK WKGIQQKYLG EIEEGFSPLP VKKLKMYDQE IVGVKSLEVF
     AHDIYGDTDP SGMMYDEPPI KFVRQGDVYE VQLKLMFANP VDIDVWVTGD ELFVQIGNQR
     KIITLPVSLT GLEPGDAVFK DKWLHIPFDL EKQGQHHRTR EYNKA