ID   ARSA_SYNY3              Reviewed;         396 AA.
AC   Q55794;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 133.
DE   RecName: Full=Putative arsenical pump-driving ATPase;
DE            EC=7.3.2.7;
DE   AltName: Full=Arsenical resistance ATPase;
DE   AltName: Full=Arsenite-translocating ATPase;
DE   AltName: Full=Arsenite-transporting ATPase;
GN   OrderedLocusNames=sll0086;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT   from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Anion-transporting ATPase. Catalyzes the extrusion of
CC       arsenite (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:11348, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29242, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.3.2.7;
CC   -!- SIMILARITY: Belongs to the arsA ATPase family. {ECO:0000305}.
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DR   EMBL; BA000022; BAA10546.1; -; Genomic_DNA.
DR   PIR; S76602; S76602.
DR   AlphaFoldDB; Q55794; -.
DR   SMR; Q55794; -.
DR   IntAct; Q55794; 1.
DR   STRING; 1148.1001709; -.
DR   PaxDb; Q55794; -.
DR   EnsemblBacteria; BAA10546; BAA10546; BAA10546.
DR   KEGG; syn:sll0086; -.
DR   eggNOG; COG0003; Bacteria.
DR   InParanoid; Q55794; -.
DR   OMA; MDAPYEF; -.
DR   PhylomeDB; Q55794; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0015446; F:ATPase-coupled arsenite transmembrane transporter activity; IEA:UniProtKB-EC.
DR   Gene3D; 2.60.40.790; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR025723; Anion-transp_ATPase-like_dom.
DR   InterPro; IPR040612; ArsA_HSP20-like.
DR   InterPro; IPR016300; ATPase_ArsA/GET3.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10803; PTHR10803; 1.
DR   Pfam; PF02374; ArsA_ATPase; 1.
DR   Pfam; PF17886; ArsA_HSP20; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00345; GET3_arsA_TRC40; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance; ATP-binding; Nucleotide-binding; Reference proteome;
KW   Translocase.
FT   CHAIN           1..396
FT                   /note="Putative arsenical pump-driving ATPase"
FT                   /id="PRO_0000152264"
FT   BINDING         8..15
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   396 AA;  44626 MW;  0D768B195B24DEB3 CRC64;
     MRVILMTGKG GVGKTSVAAA TGLRCAELGH KTLVLSTDPA HSLADSFDLE LGHEPRLVKE
     NLWGAELDAL MELEGNWGAV KRYITQVLQA RGLDGVQAEE LAILPGMDEI FGLVRMKRHY
     DEADYDVLII DSAPTGTALR LLSLPEVGGW YMRRFYKPLQ GMSVALRPLV EPLFRPIAGF
     SLPDKEVMDA PYEFYEQIEA LEKVLTDNTQ TSVRLVTNPE KMVLKESLRA HAYLSLYNVS
     TDLVIANRIL PETIDDPFFQ RWKSNQQVYK QEIYDNFHPL PVKEAPLFSE EMCGLAALER
     LKDTLYKDED PSQVYYKENT INIVQGSNND YSLELYLPGI PKEQIQLNKT GDELNVRIGN
     HRRNLVLPQA LAALSPAGAK MEDDYLKIRF AEAVKR