ARSB_DICDI
ID ARSB_DICDI Reviewed; 563 AA.
AC Q54GU0; Q8T661;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 87.
DE RecName: Full=Putative transporter arsB;
GN Name=arsB; ORFNames=DDB_G0289879;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CitM (TC 2.A.11) transporter family.
CC {ECO:0000305}.
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DR EMBL; AF482964; AAL96262.1; -; Genomic_DNA.
DR EMBL; AAFI02000149; EAL62452.1; -; Genomic_DNA.
DR RefSeq; XP_635979.1; XM_630887.1.
DR AlphaFoldDB; Q54GU0; -.
DR STRING; 44689.DDB0191323; -.
DR PaxDb; Q54GU0; -.
DR EnsemblProtists; EAL62452; EAL62452; DDB_G0289879.
DR GeneID; 8627394; -.
DR KEGG; ddi:DDB_G0289879; -.
DR dictyBase; DDB_G0289879; arsB.
DR eggNOG; KOG2639; Eukaryota.
DR HOGENOM; CLU_011920_0_0_1; -.
DR InParanoid; Q54GU0; -.
DR OMA; FQMASKD; -.
DR PhylomeDB; Q54GU0; -.
DR PRO; PR:Q54GU0; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005887; C:integral component of plasma membrane; IGC:dictyBase.
DR GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015446; F:ATPase-coupled arsenite transmembrane transporter activity; IGC:dictyBase.
DR InterPro; IPR000802; Arsenical_pump_ArsB.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR Pfam; PF03600; CitMHS; 1.
DR PRINTS; PR00758; ARSENICPUMP.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..563
FT /note="Putative transporter arsB"
FT /id="PRO_0000363983"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..111
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 463..483
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 500..520
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 542..562
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..284
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 273..303
FT /evidence="ECO:0000255"
FT CONFLICT 47
FT /note="V -> G (in Ref. 1; AAL96262)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 563 AA; 62459 MW; 3B658A86C5E480AC CRC64;
MIDINSSSSS SSSNNNNSNN NNNNNNNNNS NVFEINSSIK PYFTCIVFVI SLIFICSSKN
IVTKHLPIGR AGSSIIGATL MVYFGIIQPK EIGSVINWDT IILLMSMMML SNYMEQANIW
GMASKILLWK CKSTSIFMVR VCLISSIMSS ILTNDTVCVT LTPIVISACK STNLTFFPFL
MAIATSANIG SSALPVGNPQ NMIIATAGGL NFFNFFKVSI VSSILGVCLN TILLLLYFKK
DLKNLNSNFN QLIETVNPKV EEIDNNHHDD DGANNQSKNE KEMENINKEV EEEQHNNDDD
DDDGFNENKN NNNNGGHAIL LVASSMDSID LSDCSIINKD KKKKENFIEI YFNSKEKSIE
TIVNIIKLIF KFRVAIILTL VLIGFFIGMH MGFTVLFGVS ILMICERKDI TDIINSVDWE
LLLFFSGLFV LVEGFDRQFE KEAWTILEPF VPIDSTHLNV LKIFIFSILI LVLCNILGNV
PLVLSLSPRL LEALAPDFTW ILLAFVSTVA GNLTLVGSVA NLIVAEKSKS YHEIGFLEYL
KFGVPSTILV ILIGVPIVVL IGK
