ID   ARSB_STAAM              Reviewed;         429 AA.
AC   P63619; Q99T95;
DT   11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Arsenical pump membrane protein;
DE   AltName: Full=Arsenic efflux pump protein;
GN   Name=arsB; OrderedLocusNames=SAV1774;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Involved in arsenical resistance. Thought to form the channel
CC       of an arsenite pump.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ArsB family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB57936.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000017; BAB57936.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; P63619; -.
DR   SMR; P63619; -.
DR   PaxDb; P63619; -.
DR   EnsemblBacteria; BAB57936; BAB57936; SAV1774.
DR   KEGG; sav:SAV1774; -.
DR   HOGENOM; CLU_043931_1_0_9; -.
DR   OMA; SWGYYFK; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd01118; ArsB_permease; 1.
DR   InterPro; IPR000802; Arsenical_pump_ArsB.
DR   Pfam; PF02040; ArsB; 1.
DR   PRINTS; PR00758; ARSENICPUMP.
DR   TIGRFAMs; TIGR00935; 2a45; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..429
FT                   /note="Arsenical pump membrane protein"
FT                   /id="PRO_0000201471"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   429 AA;  47141 MW;  2112BE3633705814 CRC64;
     MTTLATLIFL VTLLFVLWQP KGLDIGITAL TGAFIAVITG VVSFSDVFEV TGIVWNATLT
     FVSVILISLI LDKVGLFEWS AIHMLHASKG NGLKMFVYII LLGAIVAAFF ANDGAALILT
     PIVLAMVKNI GFSKRAIFPF IIASGFIADT TSLPLIVSNL VNIISADYFH VGFVRYFSRM
     IIPNLFSLLA SIIVLWLYFR KAIPKTFDDN NIKHPKDAIN DLKLFKISWI VLVILLFGYL
     ISEFTKIPVS IFTGIIAFIF LMLARKSNAV NIKQVIKGAP WNIVLFSIGM YIVVFGLRNA
     GITLILAKIL EYISNYGLFS TILGMGFISA FLSSIMNNMP TVLIDAIAIG QSNVHGMLKE
     GLIYANVIGS DLGPKITPIG SLATLLWLHV LTQKDVKISW GTYFKTGIII TIPVLFITLI
     GLYLTLIIF