ID   ARSB_STAAU              Reviewed;         429 AA.
AC   P30329;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Arsenical pump membrane protein;
DE   AltName: Full=Arsenic efflux pump protein;
GN   Name=arsB;
OS   Staphylococcus aureus.
OG   Plasmid pI258.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=1280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1534328; DOI=10.1128/jb.174.11.3684-3694.1992;
RA   Ji G., Silver S.;
RT   "Regulation and expression of the arsenic resistance operon from
RT   Staphylococcus aureus plasmid pI258.";
RL   J. Bacteriol. 174:3684-3694(1992).
CC   -!- FUNCTION: Involved in arsenical resistance. Thought to form the channel
CC       of an arsenite pump.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ArsB family. {ECO:0000305}.
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DR   EMBL; M86824; AAA25637.1; -; Genomic_DNA.
DR   PIR; C41903; C41903.
DR   RefSeq; WP_000153629.1; NZ_PUHM01000300.1.
DR   RefSeq; YP_006937608.1; NC_013319.1.
DR   RefSeq; YP_006938162.1; NC_013333.1.
DR   RefSeq; YP_006938642.1; NC_013347.1.
DR   RefSeq; YP_006938776.1; NC_013352.1.
DR   AlphaFoldDB; P30329; -.
DR   SMR; P30329; -.
DR   TCDB; 2.A.45.1.1; the arsenite-antimonite (arsb) efflux family.
DR   PRIDE; P30329; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd01118; ArsB_permease; 1.
DR   InterPro; IPR000802; Arsenical_pump_ArsB.
DR   Pfam; PF02040; ArsB; 1.
DR   PRINTS; PR00758; ARSENICPUMP.
DR   TIGRFAMs; TIGR00935; 2a45; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance; Cell membrane; Membrane; Plasmid; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..429
FT                   /note="Arsenical pump membrane protein"
FT                   /id="PRO_0000201475"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        179..199
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   429 AA;  46484 MW;  654CE9BA110A15DB CRC64;
     MTILAIVIFL LTLTFVIWQP KGLDIGITAL IGAVVAIITG VVSLSDVLEV TGIVWNATLT
     FVAVILISLI LDEIGFFEWS AIHMVKASNG NGLKMFVFIM LLGAIVAAFF ANDGAALILT
     PIVLAMVRNL GFNQKVIFPF IIASGFIADT TSLPLIVSNL VNIVSADYFD IGFIEYFSRM
     IIPNIFSLIA SILVLWLYFR KSIPKTFDTE NLSDPKSAIK DSKLFKLSWI VLAVLLVGYL
     VSEFIQIPVS IIAGIIAFIF VILARKSKAV HTKQVIKGAP WNIVVFSIGM YLVVFGLKNV
     GITTILGDVL TNISNYGLFS SIMGMGFIAA FLSSIMNNMP TVLIDAIAIG QSSATGILKE
     GMVYANVIGS DLGPKITPIG SLATLLWLHV LTQKGVKISW GTYFKTGIII TIPVLFVTLL
     GLYLTLIIF