ID   ARSB_STAEQ              Reviewed;         430 AA.
AC   Q5HRI3;
DT   08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Arsenical pump membrane protein;
DE   AltName: Full=Arsenic efflux pump protein;
GN   Name=arsB; OrderedLocusNames=SERP0210;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Involved in arsenical resistance. Thought to form the channel
CC       of an arsenite pump.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ArsB family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CP000029; AAW53574.1; -; Genomic_DNA.
DR   RefSeq; WP_002445751.1; NC_002976.3.
DR   AlphaFoldDB; Q5HRI3; -.
DR   SMR; Q5HRI3; -.
DR   STRING; 176279.SERP0210; -.
DR   EnsemblBacteria; AAW53574; AAW53574; SERP0210.
DR   KEGG; ser:SERP0210; -.
DR   eggNOG; COG1055; Bacteria.
DR   HOGENOM; CLU_043931_1_0_9; -.
DR   OMA; SWGYYFK; -.
DR   OrthoDB; 626718at2; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd01118; ArsB_permease; 1.
DR   InterPro; IPR000802; Arsenical_pump_ArsB.
DR   Pfam; PF02040; ArsB; 1.
DR   PRINTS; PR00758; ARSENICPUMP.
DR   TIGRFAMs; TIGR00935; 2a45; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..430
FT                   /note="Arsenical pump membrane protein"
FT                   /id="PRO_0000201478"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        26..46
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        181..201
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        223..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        276..296
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        317..337
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        373..393
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   430 AA;  47142 MW;  B90DF03C597E6EA9 CRC64;
     MTTVLAIVIF FITLTLIIWQ PKGLDIGISA IIGALLVIIT GVVNFTDILE VIGIVWNATL
     TFVSVILISL ILDEIGFFEW SAIHMVKASN GHGLKMFIYI MILGALIAAF FANDGAALIL
     TPIVLAMIRN LGFNNKLVFP FIIACGFIAD STSLPLVVSN LVNIVSADYF GIKFVEYLMR
     MFIPNLFSLL ASILVLWFYF RKSIPKTFDI SSISEPKDAI RDTRLFKISW IILALLLIGY
     LVSEFIHIPV SFITGAIAVI FILLARQSNV VHTKQVIKGA PWNIVIFSIG MYLVIFGLKN
     VGMTLILADI LSSIAQHGLF SSIMGMGFVS AFLSAIMNNM PTVLIDAIAI DQSHAISSIK
     EGMIYANVIG ADLGPKITPI GSLATLLWLH VLVQKGVKIS WGTYFKTGIV ITIPVLFFTL
     LGLYLTLIIF