ID   ARSB_STAES              Reviewed;         429 AA.
AC   Q8CQF4;
DT   28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Arsenical pump membrane protein;
DE   AltName: Full=Arsenic efflux pump protein;
GN   Name=arsB; OrderedLocusNames=SE_0135;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Involved in arsenical resistance. Thought to form the channel
CC       of an arsenite pump.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ArsB family. {ECO:0000305}.
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DR   EMBL; AE015929; AAO03732.1; -; Genomic_DNA.
DR   RefSeq; NP_763690.1; NC_004461.1.
DR   RefSeq; WP_002455949.1; NZ_WBME01000049.1.
DR   AlphaFoldDB; Q8CQF4; -.
DR   SMR; Q8CQF4; -.
DR   STRING; 176280.SE_0135; -.
DR   EnsemblBacteria; AAO03732; AAO03732; SE_0135.
DR   GeneID; 50017551; -.
DR   KEGG; sep:SE_0135; -.
DR   PATRIC; fig|176280.10.peg.126; -.
DR   eggNOG; COG1055; Bacteria.
DR   HOGENOM; CLU_043931_1_0_9; -.
DR   OMA; NISWIVL; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd01118; ArsB_permease; 1.
DR   InterPro; IPR000802; Arsenical_pump_ArsB.
DR   Pfam; PF02040; ArsB; 1.
DR   PRINTS; PR00758; ARSENICPUMP.
DR   TIGRFAMs; TIGR00935; 2a45; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..429
FT                   /note="Arsenical pump membrane protein"
FT                   /id="PRO_0000201477"
FT   TRANSMEM        3..23
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        25..45
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        372..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        408..428
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   429 AA;  46839 MW;  8C13C06D7F86DD6C CRC64;
     MTILAITIFI LTLIFVIWQP KGLDIGITAL IGAVIAIITG VVSFSDVLEV TGIVWNATLT
     FVAVILISLI LDEIGFFEWS AIHMVRASKG NGLKMFVYIM LLGAIVAAFF ANDGAALILT
     PIVLAMVRSL GFDKKAVFPF IIASGFIADT TSLPLIVSNL VNIVSADYFD IGFVEYFSKM
     IIPNIFSLIA SILVLWLYFR KSIPRKFDAV NIREPKEAIK DKKLFNISWI VLTVLLVGYL
     ISEFINIPVS IIAGIIALIF VLLARKSKAV HTKQVIKGAP WNIVLFSIGM YLVVFGLKNV
     GITTLLSDVL TNISSYGLFS SIMGMGFISA FLSSIMNNMP TVLIDAIAIG QSQTTSILKE
     GMIYANVIGS DLGPKITPIG SLATLLWLHV LTQKGVKISW GQYFKIGIII TIPVLFITLL
     GLYLTLIIF