ID   ARSB_YEREN              Reviewed;         429 AA.
AC   P74985;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Arsenical pump membrane protein;
DE   AltName: Full=Arsenic efflux pump protein;
GN   Name=arsB;
OS   Yersinia enterocolitica.
OG   Plasmid pYV, and Plasmid pYVe227.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=630;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=439-80 / Serotype O:9; PLASMID=pYV; TRANSPOSON=Tn2502;
RX   PubMed=9006011; DOI=10.1128/jb.179.3.612-619.1997;
RA   Neyt C., Iriarte M., Thi V.H., Cornelis G.R.;
RT   "Virulence and arsenic resistance in Yersiniae.";
RL   J. Bacteriol. 179:612-619(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=W22703 / Serotype O:9 / Biotype 2; PLASMID=pYVe227;
RA   Iriarte M., Lambermont I., Kerbourch C., Cornelis G.R.;
RT   "Detailed genetic map of the pYVe227 plasmid of Yersinia enterocolitica
RT   serotype O:9.";
RL   Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in arsenical resistance. Thought to form the channel
CC       of an arsenite pump (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ArsB family. {ECO:0000305}.
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DR   EMBL; U58366; AAB42204.1; -; Genomic_DNA.
DR   EMBL; AF102990; AAD16859.1; -; Genomic_DNA.
DR   RefSeq; NP_052439.1; NC_002120.1.
DR   RefSeq; WP_010891245.1; NZ_KN150737.1.
DR   AlphaFoldDB; P74985; -.
DR   SMR; P74985; -.
DR   PATRIC; fig|630.129.peg.4415; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015105; F:arsenite transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   CDD; cd01118; ArsB_permease; 1.
DR   InterPro; IPR000802; Arsenical_pump_ArsB.
DR   Pfam; PF02040; ArsB; 1.
DR   PRINTS; PR00758; ARSENICPUMP.
DR   TIGRFAMs; TIGR00935; 2a45; 1.
PE   3: Inferred from homology;
KW   Arsenical resistance; Cell inner membrane; Cell membrane; Membrane;
KW   Plasmid; Transmembrane; Transmembrane helix; Transport;
KW   Transposable element.
FT   CHAIN           1..429
FT                   /note="Arsenical pump membrane protein"
FT                   /id="PRO_0000201480"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        98..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        228..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        249..269
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        274..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        316..336
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        337..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        371..391
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        407..427
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   429 AA;  45497 MW;  44615F5604E5B3B1 CRC64;
     MLLAGSIFVL TLILAIWQPR GLSIGWSASI CAALALVSGV IHVGDIPVVW NIVWNATATF
     IAVIIISLLL DESGFFEWAA LHVSRWGNGR GRLLFTWIVL LGAAVAALFA NDGAALILTP
     IVIAMLLALG FSKRTTLAFV MAAGFIADTA SLPLIVSNLV NIVSADFFRL GFTEYASVML
     PVDIAAIAAT LGMLHLFFRR DIPATYDVSL LKMPASAIKD PATFRAGWIV LVLLLVGFFV
     LEPLGIPVSA IAAVGTVVLF AVAKKGHAIN TGKVLRGAPW QIVVFSLGMY LVVYGLRNAG
     LTEYLSGVLN MLADKGLLAA TFGTGFLTAF LSSVMNNMPT VLVGALSIDG STASGVIKEA
     MIYANVIGCD LGPKITPIGS LATLLWLHVL SQKNMTISWG YYFRTGIIMT LPVLFVTLAA
     LALRLSVTL