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OBG_STRGR
ID   OBG_STRGR               Reviewed;         478 AA.
AC   P95758;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=GTPase Obg {ECO:0000255|HAMAP-Rule:MF_01454};
DE            EC=3.6.5.- {ECO:0000255|HAMAP-Rule:MF_01454};
DE   AltName: Full=GTP-binding protein Obg {ECO:0000255|HAMAP-Rule:MF_01454};
GN   Name=obg {ECO:0000255|HAMAP-Rule:MF_01454};
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], POSSIBLE FUNCTION IN SPORULATION,
RP   GTP-BINDING, AND OVEREXPRESSION.
RC   STRAIN=ATCC 11984 / NBRC 13189 / SL-842;
RX   PubMed=8981995; DOI=10.1128/jb.179.1.170-179.1997;
RA   Okamoto S., Itoh M., Ochi K.;
RT   "Molecular cloning and characterization of the obg gene of Streptomyces
RT   griseus in relation to the onset of morphological differentiation.";
RL   J. Bacteriol. 179:170-179(1997).
RN   [2]
RP   REVIEW.
RX   PubMed=15737924; DOI=10.1016/j.devcel.2005.02.002;
RA   Michel B.;
RT   "Obg/CtgA, a signaling protein that controls replication, translation, and
RT   morphological development?";
RL   Dev. Cell 8:300-301(2005).
CC   -!- FUNCTION: Overexpression suppresses sporulation although cell growth
CC       rate was not reduced. Impaired differentiation was eliminated by
CC       addition of decoyinine, an inhibitor of GMP synthesis. Overexpression
CC       has no effect on streptomycin production.
CC   -!- FUNCTION: An essential GTPase which binds GTP, GDP and possibly
CC       (p)ppGpp with moderate affinity, with high nucleotide exchange rates
CC       and a fairly low GTP hydrolysis rate. Plays a role in control of the
CC       cell cycle, stress response, ribosome biogenesis and in those bacteria
CC       that undergo differentiation, in morphogenesis control.
CC       {ECO:0000255|HAMAP-Rule:MF_01454}.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01454};
CC   -!- SUBUNIT: Monomer. {ECO:0000255|HAMAP-Rule:MF_01454}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01454}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC       superfamily. OBG GTPase family. {ECO:0000255|HAMAP-Rule:MF_01454}.
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DR   EMBL; D87916; BAA13501.1; -; Genomic_DNA.
DR   RefSeq; WP_003969206.1; NZ_UAVD01000011.1.
DR   AlphaFoldDB; P95758; -.
DR   SMR; P95758; -.
DR   STRING; 1911.GCA_001715295_04040; -.
DR   GeneID; 6211583; -.
DR   OMA; VVFDWEP; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0042254; P:ribosome biogenesis; IEA:UniProtKB-UniRule.
DR   CDD; cd01898; Obg; 1.
DR   Gene3D; 2.70.210.12; -; 1.
DR   Gene3D; 3.30.300.350; -; 1.
DR   Gene3D; 3.40.50.300; -; 1.
DR   HAMAP; MF_01454; GTPase_Obg; 1.
DR   InterPro; IPR031167; G_OBG.
DR   InterPro; IPR006073; GTP-bd.
DR   InterPro; IPR014100; GTP-bd_Obg/CgtA.
DR   InterPro; IPR036346; GTP-bd_prot_GTP1/OBG_C_sf.
DR   InterPro; IPR006074; GTP1-OBG_CS.
DR   InterPro; IPR006169; GTP1_OBG_dom.
DR   InterPro; IPR036726; GTP1_OBG_dom_sf.
DR   InterPro; IPR045086; OBG_GTPase.
DR   InterPro; IPR015349; OCT_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR11702; PTHR11702; 1.
DR   Pfam; PF09269; DUF1967; 1.
DR   Pfam; PF01018; GTP1_OBG; 1.
DR   Pfam; PF01926; MMR_HSR1; 1.
DR   PRINTS; PR00326; GTP1OBG.
DR   SUPFAM; SSF102741; SSF102741; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF82051; SSF82051; 1.
DR   TIGRFAMs; TIGR02729; Obg_CgtA; 1.
DR   TIGRFAMs; TIGR03595; Obg_CgtA_exten; 1.
DR   PROSITE; PS51710; G_OBG; 1.
DR   PROSITE; PS00905; GTP1_OBG; 1.
DR   PROSITE; PS51883; OBG; 1.
DR   PROSITE; PS51881; OCT; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; GTP-binding; Hydrolase; Magnesium; Metal-binding;
KW   Nucleotide-binding.
FT   CHAIN           1..478
FT                   /note="GTPase Obg"
FT                   /id="PRO_0000386324"
FT   DOMAIN          2..159
FT                   /note="Obg"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01231"
FT   DOMAIN          160..330
FT                   /note="OBG-type G"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01454"
FT   DOMAIN          348..430
FT                   /note="OCT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01229"
FT   REGION          61..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          436..478
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        439..468
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         166..173
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01454"
FT   BINDING         173
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01454"
FT   BINDING         191..195
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01454"
FT   BINDING         193
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01454"
FT   BINDING         212..215
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01454"
FT   BINDING         282..285
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01454"
FT   BINDING         311..313
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01454"
SQ   SEQUENCE   478 AA;  51024 MW;  2E30119EA1B3E98D CRC64;
     MTTFVDRVEL HAAAGNGGHG CASVHREKFK PLGGPDGGNG GRGGDVILVV EQSVTTLLDY
     HHSPHRKATN GQPGAGDNRS GKDGQDLVLP VPDGTVVLDK AGNVLADLVG QGTTFVAGQG
     GRGGLGNAAL ASARRKAPGF ALLGEPGESR DIVLELKTVA DVALVGYPSA GKSSLISVLS
     AAKPKIADYP FTTLVPNLGV VTAGSTVYTI ADVPGLIPGA SQGKGLGLEF LRHVERCSVL
     VHVLDTATLE SDRDPVSDLD MIEEELRLYG GLENRPRIVA LNKVDIPDGQ DLADMIRPDL
     EARGYRVFEV SAIAHKGLKE LSFALAGIIA EARATKPKEE ATRIVIRPRA VDDAGFTVTL
     EDDGIYRVRG EKPERWVRQT DFNNDEAVGY LADRLNRLGV EDSLMKAGAR AGDGVAIGPE
     ENAVVFDWEP TVTAGAEMLG RRGEDHRLEE PRPAAQRRRE RDAERDDAEK EYDEFDPF
 
 
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