A28_FOWPN
ID A28_FOWPN Reviewed; 141 AA.
AC Q9J541;
DT 29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 62.
DE RecName: Full=Envelope protein A28 homolog;
DE AltName: Full=Protein FPV192;
GN OrderedLocusNames=FPV192;
OS Fowlpox virus (strain NVSL) (FPV).
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Avipoxvirus.
OX NCBI_TaxID=928301;
OH NCBI_TaxID=7742; Vertebrata.
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10729156; DOI=10.1128/jvi.74.8.3815-3831.2000;
RA Afonso C.L., Tulman E.R., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT "The genome of fowlpox virus.";
RL J. Virol. 74:3815-3831(2000).
CC -!- FUNCTION: Envelope protein required for virus entry into host cell and
CC for cell-cell fusion (syncytium formation). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC II membrane protein {ECO:0000305}. Note=Component of the intracellular
CC mature virion (IMV) membrane. {ECO:0000250}.
CC -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC that operates on the cytoplasmic side of the MV membranes (By
CC similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the poxviridae A28 protein family.
CC {ECO:0000305}.
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DR EMBL; AF198100; AAF44536.1; -; Genomic_DNA.
DR RefSeq; NP_039155.1; NC_002188.1.
DR GeneID; 1486764; -.
DR KEGG; vg:1486764; -.
DR Proteomes; UP000008597; Genome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR InterPro; IPR007664; Poxvirus_A28.
DR Pfam; PF04584; Pox_A28; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Fusion of virus membrane with host membrane; Late protein;
KW Membrane; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix; Viral envelope protein;
KW Viral penetration into host cytoplasm; Virion; Virus entry into host cell.
FT CHAIN 1..141
FT /note="Envelope protein A28 homolog"
FT /id="PRO_0000099291"
FT TRANSMEM 1..21
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 22..141
FT /note="Virion surface"
FT /evidence="ECO:0000255"
SQ SEQUENCE 141 AA; 16114 MW; 26511BF203424318 CRC64;
MDALFVFIII LATAVICLFL FQAYTIYDNY HNIIEFNEKY GGLEYSRSPG GLYIDKRVFD
PNDSETDPKA KWRCVNYNNN QYASASKFGY LATSSRNPVL FTNLEDCVYY NYTRGEIGTI
WNPCAEYGEG SAECSTLKSH L