OBP1A_MOUSE
ID OBP1A_MOUSE Reviewed; 163 AA.
AC Q9D3H2; P97336;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Odorant-binding protein 1a {ECO:0000305};
DE AltName: Full=Odorant-binding protein IA {ECO:0000303|PubMed:8529023};
DE Flags: Precursor;
GN Name=Obp1a {ECO:0000303|PubMed:8529023};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAB30751.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB30751.2};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:EDL29193.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAI25515.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain {ECO:0000312|EMBL:AAI25515.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000312|EMBL:CAA71867.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-163.
RC TISSUE=Nasal mucosa {ECO:0000312|EMBL:CAA71867.1};
RX PubMed=9661663; DOI=10.1016/s0378-1119(98)00131-0;
RA Pes D., Mameli M., Andreini I., Krieger J., Weber M., Breer H., Pelosi P.;
RT "Cloning and expression of odorant-binding proteins Ia and Ib from mouse
RT nasal tissue.";
RL Gene 212:49-55(1998).
RN [6] {ECO:0000305}
RP PROTEIN SEQUENCE OF 17-44, FUNCTION, TISSUE SPECIFICITY, AND BLOCKAGE OF
RP N-TERMINUS.
RX PubMed=8529023; DOI=10.1016/0305-0491(95)00063-1;
RA Pes D., Pelosi P.;
RT "Odorant-binding proteins of the mouse.";
RL Comp. Biochem. Physiol. 112B:471-479(1995).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Binds the chemical odorant 2-isobutyl-3-methoxypyrazine.
CC {ECO:0000269|PubMed:8529023}.
CC -!- SUBUNIT: May form a heterodimer with OBP1B.
CC {ECO:0000305|PubMed:8529023}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in nasal mucosa (at protein level)
CC (PubMed:8529023). Specifically detected in septal and lateral nasal
CC glands (PubMed:9661663). {ECO:0000269|PubMed:8529023,
CC ECO:0000269|PubMed:9661663}.
CC -!- PTM: The N-terminus may be blocked. {ECO:0000269|PubMed:8529023}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AK017455; BAB30751.2; -; mRNA.
DR EMBL; AL671961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466576; EDL29193.1; -; Genomic_DNA.
DR EMBL; BC125514; AAI25515.1; -; mRNA.
DR EMBL; BC125516; AAI25517.1; -; mRNA.
DR EMBL; Y10971; CAA71867.1; -; Genomic_DNA.
DR CCDS; CCDS30251.1; -.
DR RefSeq; NP_032780.2; NM_008754.2.
DR AlphaFoldDB; Q9D3H2; -.
DR SMR; Q9D3H2; -.
DR STRING; 10090.ENSMUSP00000085531; -.
DR iPTMnet; Q9D3H2; -.
DR PhosphoSitePlus; Q9D3H2; -.
DR EPD; Q9D3H2; -.
DR MaxQB; Q9D3H2; -.
DR PaxDb; Q9D3H2; -.
DR PRIDE; Q9D3H2; -.
DR ProteomicsDB; 294265; -.
DR DNASU; 18249; -.
DR Ensembl; ENSMUST00000088201; ENSMUSP00000085531; ENSMUSG00000067684.
DR GeneID; 18249; -.
DR KEGG; mmu:18249; -.
DR UCSC; uc009tqu.1; mouse.
DR CTD; 18249; -.
DR MGI; MGI:1277949; Obp1a.
DR VEuPathDB; HostDB:ENSMUSG00000067684; -.
DR eggNOG; ENOG502TDZD; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_094061_4_2_1; -.
DR InParanoid; Q9D3H2; -.
DR OMA; TGDWRSI; -.
DR OrthoDB; 1357921at2759; -.
DR PhylomeDB; Q9D3H2; -.
DR TreeFam; TF338197; -.
DR BioGRID-ORCS; 18249; 4 hits in 69 CRISPR screens.
DR ChiTaRS; Obp1a; mouse.
DR PRO; PR:Q9D3H2; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9D3H2; protein.
DR Bgee; ENSMUSG00000067684; Expressed in lacrimal gland and 15 other tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005549; F:odorant binding; IDA:MGI.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002448; OBP-like.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01173; ODORANTBNDNG.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Olfaction; Reference proteome;
KW Secreted; Sensory transduction; Signal; Transport.
FT SIGNAL 1..16
FT /evidence="ECO:0000269|PubMed:8529023"
FT CHAIN 17..163
FT /note="Odorant-binding protein 1a"
FT /id="PRO_5006751578"
FT DISULFID 50..54
FT /evidence="ECO:0000250|UniProtKB:P08937"
FT DISULFID 69..161
FT /evidence="ECO:0000250|UniProtKB:P08937"
SQ SEQUENCE 163 AA; 18469 MW; A26B3927E1D2BE8A CRC64;
MAKFLLLALT FGLAHAAMEG PWKTVAIAAD RVDKIERGGE LRIYCRSLTC EKECKEMKVT
FYVNENGQCS LTTITGYLQE DGKTYKTQFQ GNNRYKLVDE SPENLTFYSE NVDRADRKTK
LLFILGHGPL TSEQKEKFAE LAEEKGIPAG NIREVLITDY CPE
