OBP1B_MOUSE
ID OBP1B_MOUSE Reviewed; 171 AA.
AC A2AEP0; P97337;
DT 08-JUN-2016, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Odorant-binding protein 1b {ECO:0000305};
DE AltName: Full=Odorant-binding protein IB {ECO:0000303|PubMed:8529023};
DE Flags: Precursor;
GN Name=Obp1b {ECO:0000303|PubMed:8529023};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000312|Proteomes:UP000000589};
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:CAA71868.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-171.
RC TISSUE=Nasal mucosa {ECO:0000312|EMBL:CAA71868.1};
RX PubMed=9661663; DOI=10.1016/s0378-1119(98)00131-0;
RA Pes D., Mameli M., Andreini I., Krieger J., Weber M., Breer H., Pelosi P.;
RT "Cloning and expression of odorant-binding proteins Ia and Ib from mouse
RT nasal tissue.";
RL Gene 212:49-55(1998).
RN [3] {ECO:0000305}
RP PROTEIN SEQUENCE OF 20-43, FUNCTION, TISSUE SPECIFICITY, AND BLOCKAGE OF
RP N-TERMINUS.
RX PubMed=8529023; DOI=10.1016/0305-0491(95)00063-1;
RA Pes D., Pelosi P.;
RT "Odorant-binding proteins of the mouse.";
RL Comp. Biochem. Physiol. 112B:471-479(1995).
CC -!- FUNCTION: Binds the chemical odorant 2-isobutyl-3-methoxypyrazine.
CC {ECO:0000269|PubMed:8529023}.
CC -!- SUBUNIT: May form a heterodimer with OBP1A.
CC {ECO:0000305|PubMed:8529023}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in nasal mucosa (at protein level)
CC (PubMed:8529023). Specifically detected in septal and lateral nasal
CC glands (PubMed:9661663). {ECO:0000269|PubMed:8529023,
CC ECO:0000269|PubMed:9661663}.
CC -!- PTM: The N-terminus may be blocked. {ECO:0000269|PubMed:8529023}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AL671961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX571702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; Y10972; CAA71868.1; -; Genomic_DNA.
DR CCDS; CCDS81146.1; -.
DR RefSeq; NP_001297257.1; NM_001310328.1.
DR AlphaFoldDB; A2AEP0; -.
DR SMR; A2AEP0; -.
DR STRING; 10090.ENSMUSP00000085528; -.
DR MaxQB; A2AEP0; -.
DR PaxDb; A2AEP0; -.
DR PeptideAtlas; A2AEP0; -.
DR PRIDE; A2AEP0; -.
DR ProteomicsDB; 294056; -.
DR Ensembl; ENSMUST00000088198; ENSMUSP00000085528; ENSMUSG00000067679.
DR GeneID; 628991; -.
DR KEGG; mmu:628991; -.
DR UCSC; uc057asa.1; mouse.
DR CTD; 628991; -.
DR MGI; MGI:1277948; Obp1b.
DR VEuPathDB; HostDB:ENSMUSG00000067679; -.
DR eggNOG; ENOG502TDZD; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_094061_4_2_1; -.
DR InParanoid; A2AEP0; -.
DR OMA; RELAHED; -.
DR OrthoDB; 1357921at2759; -.
DR PhylomeDB; A2AEP0; -.
DR TreeFam; TF338197; -.
DR BioGRID-ORCS; 628991; 0 hits in 2 CRISPR screens.
DR PRO; PR:A2AEP0; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; A2AEP0; protein.
DR Genevisible; A2AEP0; MM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005549; F:odorant binding; ISO:MGI.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002448; OBP-like.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01173; ODORANTBNDNG.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Disulfide bond; Olfaction; Reference proteome;
KW Secreted; Sensory transduction; Signal; Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000269|PubMed:8529023"
FT CHAIN 20..171
FT /note="Odorant-binding protein 1b"
FT /id="PRO_5002642467"
FT DISULFID 57..61
FT /evidence="ECO:0000250|UniProtKB:P08937"
FT DISULFID 76..169
FT /evidence="ECO:0000250|UniProtKB:P08937"
SQ SEQUENCE 171 AA; 19394 MW; 8A224AA38790624C CRC64;
MMVKFLLLAL VFGLAHVHAH DHPELQGQWK TTAIMADNID KIETSGPLEL FVREITCDEG
CQKMKVTFYV KQNGQCSLTT VTGYKQEDGK TFKNQYEGEN NYKLLKATSE NLVFYDENVD
RASRKTKLLY ILGKGEALTH EQKERLTELA TQKGIPAGNL RELAHEDTCP E
