ID   OBP1_MANSE              Reviewed;         166 AA.
AC   P31418;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1993, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=General odorant-binding protein 1;
DE            Short=GOBP 1;
DE   Flags: Precursor;
GN   Name=GOBP1;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1719155; DOI=10.1523/jneurosci.11-10-02972.1991;
RA   Vogt R.G., Rybczynski R., Lerner M.R.;
RT   "Molecular cloning and sequencing of general odorant-binding proteins GOBP1
RT   and GOBP2 from the tobacco hawk moth Manduca sexta: comparisons with other
RT   insect OBPs and their signal peptides.";
RL   J. Neurosci. 11:2972-2984(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 23-56.
RX   PubMed=2010751; DOI=10.1002/neu.480220108;
RA   Vogt R.G., Prestwich G.D., Lerner M.R.;
RT   "Odorant-binding-protein subfamilies associate with distinct classes of
RT   olfactory receptor neurons in insects.";
RL   J. Neurobiol. 22:74-84(1991).
CC   -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC       dendrites and are thought to aid in the capture and transport of
CC       hydrophobic odorants into and through this fluid.
CC   -!- SUBUNIT: Homodimer. {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Olfactory tissue; expressed by the glia-like
CC       support cells that ensheathe the sensory neurons and line the base of
CC       the sensillum lumen.
CC   -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR   EMBL; M73797; AAA29315.1; -; mRNA.
DR   PIR; B44821; B44821.
DR   AlphaFoldDB; P31418; -.
DR   SMR; P31418; -.
DR   GO; GO:0005549; F:odorant binding; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.238.20; -; 1.
DR   InterPro; IPR006072; Odorant/phero-bd_Lep.
DR   InterPro; IPR006170; PBP/GOBP.
DR   InterPro; IPR036728; PBP_GOBP_sf.
DR   Pfam; PF01395; PBP_GOBP; 1.
DR   PIRSF; PIRSF015604; Odorant/phero_bd; 1.
DR   PRINTS; PR00484; PBPGOBP.
DR   SMART; SM00708; PhBP; 1.
DR   SUPFAM; SSF47565; SSF47565; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Olfaction; Sensory transduction;
KW   Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000269|PubMed:2010751"
FT   CHAIN           23..166
FT                   /note="General odorant-binding protein 1"
FT                   /id="PRO_0000012584"
FT   DISULFID        41..76
FT                   /evidence="ECO:0000250"
FT   DISULFID        72..130
FT                   /evidence="ECO:0000250"
FT   DISULFID        119..139
FT                   /evidence="ECO:0000250"
FT   CONFLICT        41
FT                   /note="C -> N (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   166 AA;  19117 MW;  571A23342404DE35 CRC64;
     MGQDTRSLVL VVLVGLVGAV SADVQVMKDV TLGFGQALEQ CREESQLTEE KMEEFFHFWR
     EDFKFEHREL GCALQCMSRH FNLLTDSSRM HHENTDKFIK SFPNGAVLSK TMVELIHNCE
     LQHDAEEDHC WRILRVAECF KISCTKAGIA PSMEVMMAEF IMELKQ