OBP1_SCHPO
ID OBP1_SCHPO Reviewed; 516 AA.
AC O94512;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Oxysterol-binding protein-like protein 1;
GN Name=obp1; ORFNames=SPBC646.08c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182, AND IDENTIFICATION BY
RP MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum
CC {ECO:0000269|PubMed:16823372}.
CC -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CU329671; CAA22812.1; -; Genomic_DNA.
DR PIR; T40584; T40584.
DR RefSeq; NP_595366.1; NM_001021274.2.
DR AlphaFoldDB; O94512; -.
DR SMR; O94512; -.
DR BioGRID; 277608; 24.
DR STRING; 4896.SPBC646.08c.1; -.
DR iPTMnet; O94512; -.
DR MaxQB; O94512; -.
DR PaxDb; O94512; -.
DR PRIDE; O94512; -.
DR EnsemblFungi; SPBC646.08c.1; SPBC646.08c.1:pep; SPBC646.08c.
DR GeneID; 2541093; -.
DR KEGG; spo:SPBC646.08c; -.
DR PomBase; SPBC646.08c; -.
DR VEuPathDB; FungiDB:SPBC646.08c; -.
DR eggNOG; KOG2210; Eukaryota.
DR HOGENOM; CLU_029722_0_0_1; -.
DR InParanoid; O94512; -.
DR OMA; ILRGSFY; -.
DR PhylomeDB; O94512; -.
DR Reactome; R-SPO-1482801; Acyl chain remodelling of PS.
DR PRO; PR:O94512; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:PomBase.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008142; F:oxysterol binding; ISO:PomBase.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0120015; F:sterol transfer activity; ISO:PomBase.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; NAS:PomBase.
DR GO; GO:0015918; P:sterol transport; ISO:PomBase.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR PANTHER; PTHR10972; PTHR10972; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR SUPFAM; SSF144000; SSF144000; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Phosphoprotein; Reference proteome.
FT CHAIN 1..516
FT /note="Oxysterol-binding protein-like protein 1"
FT /id="PRO_0000315946"
FT REGION 168..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 175..196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 213..240
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 182
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 516 AA; 58692 MW; 653AD8F56C9FED9C CRC64;
MPNPNQAIKK ENEPIQVENP TELVRDDGEV EGYQKEEGKF KLVLSILKQC IGVKDIASLR
FSLPAQLLEP VGNLEYWNYV DRPDYFAVMG DSDDELERML GVLRWWFTKD LRFVRGRVVK
PYNSVLGEFF RCKWVVTDPT VREDHTLDPD SSQLPTYKTE YSETTKFPLG KSYRPKASRT
TSSQSVASTM TKSSTKTSKK KSSKKNSKSE SNQDSSNDRS STAPSTAESN NEHLSSSQKS
KHSIVFMAEQ TSHHPAVSAF YVTCPSKGIE VYGQDQIAVG FTGTSFKVCA GDLNKGVYVR
FNKRDNEEYL CTHPSASVGG ILRGNLHINL LDSTVILCPK TRIKTIITYI EERWLGKPRS
LVEGVCYRYD PSNDTIDSIK AVPKENILAT FKGNWRNCIF YSYAGESESR MLVDLNELDL
VHKRCPPLDK QFPFESRKIW FPVTHNILAK HYTQATKAKQ EIEDQQRQAS AAREESHTEW
KPRFFVPDEK EGRPTLTEEG KKVLEQSLSD EYIHGS
