OBP2A_MOUSE
ID OBP2A_MOUSE Reviewed; 176 AA.
AC Q8K1H9;
DT 29-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Odorant-binding protein 2a;
DE AltName: Full=Epididymal-specific lipocalin-13;
DE Flags: Precursor;
GN Name=Obp2a; Synonyms=Lcn13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C57BL/6 X DBA/2; TISSUE=Epididymis;
RX PubMed=15363845; DOI=10.1016/j.gene.2004.06.027;
RA Suzuki K., Lareyre J.-J., Sanchez D., Gutierrez G., Araki Y., Matusik R.J.,
RA Orgebin-Crist M.-C.;
RT "Molecular evolution of epididymal lipocalin genes localized on mouse
RT chromosome 2.";
RL Gene 339:49-59(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in male fertility. May act as a retinoid
CC carrier protein within the epididymis.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in epididymis.
CC {ECO:0000269|PubMed:15363845}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; BC027556; AAH27556.1; -; mRNA.
DR EMBL; AY360148; AAR11375.1; -; mRNA.
DR CCDS; CCDS15788.1; -.
DR RefSeq; NP_705786.1; NM_153558.1.
DR AlphaFoldDB; Q8K1H9; -.
DR SMR; Q8K1H9; -.
DR BioGRID; 230649; 4.
DR STRING; 10090.ENSMUSP00000076851; -.
DR GlyGen; Q8K1H9; 2 sites.
DR iPTMnet; Q8K1H9; -.
DR PhosphoSitePlus; Q8K1H9; -.
DR MaxQB; Q8K1H9; -.
DR PaxDb; Q8K1H9; -.
DR PRIDE; Q8K1H9; -.
DR ProteomicsDB; 293824; -.
DR DNASU; 227627; -.
DR Ensembl; ENSMUST00000077667; ENSMUSP00000076851; ENSMUSG00000062061.
DR GeneID; 227627; -.
DR KEGG; mmu:227627; -.
DR UCSC; uc008itf.1; mouse.
DR CTD; 29991; -.
DR MGI; MGI:2387617; Obp2a.
DR VEuPathDB; HostDB:ENSMUSG00000062061; -.
DR eggNOG; ENOG502S22P; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_125034_0_0_1; -.
DR InParanoid; Q8K1H9; -.
DR OMA; TENCIPE; -.
DR OrthoDB; 1450978at2759; -.
DR PhylomeDB; Q8K1H9; -.
DR TreeFam; TF338197; -.
DR BioGRID-ORCS; 227627; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q8K1H9; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8K1H9; protein.
DR Bgee; ENSMUSG00000062061; Expressed in olfactory epithelium and 13 other tissues.
DR Genevisible; Q8K1H9; MM.
DR GO; GO:0005615; C:extracellular space; IDA:MGI.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR GO; GO:0042593; P:glucose homeostasis; IDA:MGI.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IMP:MGI.
DR GO; GO:0045721; P:negative regulation of gluconeogenesis; IMP:MGI.
DR GO; GO:0051055; P:negative regulation of lipid biosynthetic process; IDA:MGI.
DR GO; GO:0032000; P:positive regulation of fatty acid beta-oxidation; IDA:MGI.
DR GO; GO:0010906; P:regulation of glucose metabolic process; IMP:MGI.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002450; von_Ebner_gland.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01175; VNEBNERGLAND.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal;
KW Transport.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..176
FT /note="Odorant-binding protein 2a"
FT /id="PRO_0000017924"
FT CARBOHYD 42
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 79..172
FT /evidence="ECO:0000250"
SQ SEQUENCE 176 AA; 19996 MW; 1AE75207D6C70B2F CRC64;
MKSLLLTILL LGLVAVLKAQ EAPPDDLVDY SGIWYAKAMV HNGTLPSHKI PSIVFPVRII
ALEEGDLETT VVFWNNGHCR EFKFVMKKTE EPGKYTAFHN TKVIHVEKTS VNEHYIFYCE
GRHNGTSSFG MGKLMGRDSG ENPEAMEEFK NFIKRMNLRL ENMFVPEIGD KCVESD
