OBP2B_HUMAN
ID OBP2B_HUMAN Reviewed; 170 AA.
AC Q9NPH6; Q5VSP6; Q9NY51; Q9NY52;
DT 03-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Odorant-binding protein 2b;
DE AltName: Full=Odorant-binding protein IIb;
DE Short=OBPIIb;
DE Flags: Precursor;
GN Name=OBP2B; ORFNames=UNQ653/PRO1283;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS BA; BB AND BG).
RX PubMed=10607840; DOI=10.1093/hmg/9.2.289;
RA Lacazette E., Gachon A.-M., Pitiot G.;
RT "A novel human odorant-binding protein gene family resulting from genomic
RT duplicons at 9q34: differential expression in the oral and genital
RT spheres.";
RL Hum. Mol. Genet. 9:289-301(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BA).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Probably binds and transports small hydrophobic volatile
CC molecules.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=Ba;
CC IsoId=Q9NPH6-1; Sequence=Displayed;
CC Name=Bb;
CC IsoId=Q9NPH6-2; Sequence=VSP_003138;
CC Name=Bg;
CC IsoId=Q9NPH6-3; Sequence=VSP_003139;
CC -!- TISSUE SPECIFICITY: Strongly expressed in genital sphere organs such as
CC the prostate and mammary glands.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR EMBL; AJ251025; CAB71322.1; -; Genomic_DNA.
DR EMBL; AJ251026; CAB71323.1; -; mRNA.
DR EMBL; AJ251027; CAB71324.1; -; mRNA.
DR EMBL; AJ251028; CAB71325.1; -; mRNA.
DR EMBL; AY358981; AAQ89340.1; -; mRNA.
DR EMBL; AL732364; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC096717; AAH96717.1; -; mRNA.
DR EMBL; BC098125; AAH98125.1; -; mRNA.
DR EMBL; BC098151; AAH98151.1; -; mRNA.
DR EMBL; BC098340; AAH98340.1; -; mRNA.
DR CCDS; CCDS6961.1; -. [Q9NPH6-1]
DR RefSeq; NP_001275916.1; NM_001288987.1. [Q9NPH6-1]
DR RefSeq; NP_055396.1; NM_014581.3. [Q9NPH6-1]
DR AlphaFoldDB; Q9NPH6; -.
DR SMR; Q9NPH6; -.
DR BioGRID; 119014; 2.
DR IntAct; Q9NPH6; 1.
DR STRING; 9606.ENSP00000484615; -.
DR iPTMnet; Q9NPH6; -.
DR PhosphoSitePlus; Q9NPH6; -.
DR BioMuta; OBP2B; -.
DR MassIVE; Q9NPH6; -.
DR PaxDb; Q9NPH6; -.
DR PeptideAtlas; Q9NPH6; -.
DR PRIDE; Q9NPH6; -.
DR ProteomicsDB; 82010; -. [Q9NPH6-1]
DR ProteomicsDB; 82011; -. [Q9NPH6-2]
DR TopDownProteomics; Q9NPH6-2; -. [Q9NPH6-2]
DR TopDownProteomics; Q9NPH6-3; -. [Q9NPH6-3]
DR Antibodypedia; 63951; 34 antibodies from 7 providers.
DR DNASU; 29989; -.
DR Ensembl; ENST00000372034.8; ENSP00000361104.3; ENSG00000171102.16. [Q9NPH6-1]
DR Ensembl; ENST00000473737.5; ENSP00000434927.1; ENSG00000171102.16. [Q9NPH6-2]
DR Ensembl; ENST00000618116.4; ENSP00000484615.1; ENSG00000171102.16. [Q9NPH6-1]
DR Ensembl; ENST00000627758.2; ENSP00000487521.1; ENSG00000280584.2. [Q9NPH6-1]
DR Ensembl; ENST00000628865.2; ENSP00000486108.1; ENSG00000280584.2. [Q9NPH6-1]
DR Ensembl; ENST00000630166.2; ENSP00000486815.1; ENSG00000280584.2. [Q9NPH6-2]
DR GeneID; 29989; -.
DR KEGG; hsa:29989; -.
DR MANE-Select; ENST00000372034.8; ENSP00000361104.3; NM_014581.4; NP_055396.1.
DR UCSC; uc004ccz.5; human. [Q9NPH6-1]
DR CTD; 29989; -.
DR DisGeNET; 29989; -.
DR GeneCards; OBP2B; -.
DR HGNC; HGNC:23381; OBP2B.
DR HPA; ENSG00000171102; Tissue enhanced (skin, testis).
DR MIM; 604606; gene.
DR neXtProt; NX_Q9NPH6; -.
DR OpenTargets; ENSG00000171102; -.
DR PharmGKB; PA134883553; -.
DR VEuPathDB; HostDB:ENSG00000171102; -.
DR eggNOG; ENOG502S22P; Eukaryota.
DR GeneTree; ENSGT01050000244868; -.
DR HOGENOM; CLU_125034_0_0_1; -.
DR InParanoid; Q9NPH6; -.
DR OMA; YIFYCED; -.
DR OrthoDB; 1450978at2759; -.
DR PhylomeDB; Q9NPH6; -.
DR TreeFam; TF338197; -.
DR PathwayCommons; Q9NPH6; -.
DR SignaLink; Q9NPH6; -.
DR BioGRID-ORCS; 29989; 7 hits in 643 CRISPR screens.
DR GenomeRNAi; 29989; -.
DR Pharos; Q9NPH6; Tdark.
DR PRO; PR:Q9NPH6; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9NPH6; protein.
DR Bgee; ENSG00000171102; Expressed in right testis and 49 other tissues.
DR ExpressionAtlas; Q9NPH6; baseline and differential.
DR Genevisible; Q9NPH6; HS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005549; F:odorant binding; NAS:UniProtKB.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR GO; GO:0007635; P:chemosensory behavior; TAS:ProtInc.
DR GO; GO:0007608; P:sensory perception of smell; NAS:UniProtKB.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002450; von_Ebner_gland.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01175; VNEBNERGLAND.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; Olfaction; Reference proteome;
KW Secreted; Sensory transduction; Signal; Transport.
FT SIGNAL 1..15
FT /evidence="ECO:0000255"
FT CHAIN 16..170
FT /note="Odorant-binding protein 2b"
FT /id="PRO_0000017938"
FT DISULFID 74..166
FT /evidence="ECO:0000250"
FT VAR_SEQ 25..170
FT /note="ITGTWYVKAMVVDKDFPEDRRPRKVSPVKVTALGGGKLEATFTFMREDRCIQ
FT KKILMRKTEEPGKYSAYGGRKLMYLQELPRRDHYIFYCKDQHHGGLLHMGKLVGRNSDT
FT NREALEEFKKLVQRKGLSEEDIFTPLQTGSCVPEH -> EGGSVHPEENPDAEDGGAWQ
FT IQRLWGQEAHIPAGAAQEGPLHLLLQRPAPWGPAPHGKACG (in isoform Bg)"
FT /evidence="ECO:0000303|PubMed:10607840"
FT /id="VSP_003139"
FT VAR_SEQ 93..170
FT /note="YGGRKLMYLQELPRRDHYIFYCKDQHHGGLLHMGKLVGRNSDTNREALEEFK
FT KLVQRKGLSEEDIFTPLQTGSCVPEH -> CLSAVEMDQITPALWEALAIDTLRKLRIG
FT TRRPRIRWGQEAHVPAGAAQEGPLHLLLQRPAPWGPAPHGKACG (in isoform
FT Bb)"
FT /evidence="ECO:0000303|PubMed:10607840"
FT /id="VSP_003138"
FT VARIANT 167
FT /note="V -> I (in dbSNP:rs11244035)"
FT /id="VAR_050177"
SQ SEQUENCE 170 AA; 19457 MW; 344FBC37E70739C1 CRC64;
MKTLFLGVTL GLAAALSFTL EEEDITGTWY VKAMVVDKDF PEDRRPRKVS PVKVTALGGG
KLEATFTFMR EDRCIQKKIL MRKTEEPGKY SAYGGRKLMY LQELPRRDHY IFYCKDQHHG
GLLHMGKLVG RNSDTNREAL EEFKKLVQRK GLSEEDIFTP LQTGSCVPEH
