ID   OBP45_AEDAE             Reviewed;         260 AA.
AC   Q16S34;
DT   07-JAN-2015, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=General odorant-binding protein 45 {ECO:0000303|PubMed:24367904};
DE   Flags: Precursor;
GN   Name=Obp45 {ECO:0000303|PubMed:24367904};
GN   ORFNames=AAEL010714 {ECO:0000312|EMBL:EAT37277.1};
OS   Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Culicinae; Aedini; Aedes; Stegomyia.
OX   NCBI_TaxID=7159 {ECO:0000312|Proteomes:UP000008820};
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND INDUCTION.
RC   STRAIN=Higgs white eye {ECO:0000303|PubMed:24367904};
RX   PubMed=24367904; DOI=10.1186/1756-3305-6-364;
RA   Costa-da-Silva A.L., Kojin B.B., Marinotti O., James A.A., Capurro M.L.;
RT   "Expression and accumulation of the two-domain odorant-binding protein
RT   AaegOBP45 in the ovaries of blood-fed Aedes aegypti.";
RL   Parasit. Vectors 6:364-364(2013).
RN   [2] {ECO:0000312|Proteomes:UP000008820}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LVPib12 {ECO:0000312|Proteomes:UP000008820};
RX   PubMed=17510324; DOI=10.1126/science.1138878;
RA   Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA   Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA   Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA   Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA   Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA   Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA   El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA   Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA   Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA   Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA   Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA   Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA   Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA   Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA   Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA   Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA   Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT   "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL   Science 316:1718-1723(2007).
CC   -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC       dendrites and thought to aid in the capture and transport of
CC       hydrophobic odorants into and through this fluid. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in the ovary at 48 and 72 hours post
CC       blood meal (PBM) but not at 12 hours PBM (at protein level). Expressed
CC       only in females with high levels in ovaries and lower levels in the fat
CC       body. Not detected in the midgut. Not detected in the head at 48 hours
CC       PBM. {ECO:0000269|PubMed:24367904}.
CC   -!- INDUCTION: By blood feed. Accumulates highly at 48 hours post blood
CC       meal. {ECO:0000269|PubMed:24367904}.
CC   -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000255}.
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DR   EMBL; CH477685; EAT37277.1; -; Genomic_DNA.
DR   RefSeq; XP_001661044.1; XM_001660994.1.
DR   AlphaFoldDB; Q16S34; -.
DR   STRING; 7159.AAEL010714-PA; -.
DR   VEuPathDB; VectorBase:AAEL022697; -.
DR   eggNOG; ENOG502RTID; Eukaryota.
DR   HOGENOM; CLU_057764_0_0_1; -.
DR   InParanoid; Q16S34; -.
DR   OMA; HERTECC; -.
DR   PhylomeDB; Q16S34; -.
DR   Proteomes; UP000008820; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005549; F:odorant binding; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.238.20; -; 2.
DR   InterPro; IPR006170; PBP/GOBP.
DR   InterPro; IPR036728; PBP_GOBP_sf.
DR   Pfam; PF01395; PBP_GOBP; 1.
DR   SUPFAM; SSF47565; SSF47565; 2.
PE   1: Evidence at protein level;
KW   Disulfide bond; Olfaction; Reference proteome; Secreted;
KW   Sensory transduction; Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..260
FT                   /note="General odorant-binding protein 45"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000431653"
FT   DISULFID        177..230
FT                   /evidence="ECO:0000250|UniProtKB:P34174"
SQ   SEQUENCE   260 AA;  29321 MW;  E99D888619845342 CRC64;
     MELKTCCIIL PLLCTLTSYA EALDHAAILK SPNELQLECS KYLPSIDVSQ NVDCYDRCIG
     LVGRFWNDSI GRPAQTIARY YQPDTGSQDH ITRTDQCLCE KVLTVPRNAY CQRASSGLQC
     YLDNYGQLLT GTPQFVPVTE IRAAQIFWDC AQMLQISRDR LTQIFKDGYN KTSEGRCLIR
     CFLVRAGLYS DRQGPNIGRF AVQCEGYTAE YEQAVVSCYD RLKKESLDSC SLATRTMDEC
     IQGNQFSSSD IDGLEKLEVQ