ID   OBP66_ANOGA             Reviewed;         212 AA.
AC   A0NBD9;
DT   01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=General odorant-binding protein 66;
DE   Flags: Precursor;
GN   Name=Obp66; ORFNames=AGAP007283;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=23292137; DOI=10.1093/gbe/evs131;
RA   Manoharan M., Ng Fuk Chong M., Vaitinadapoule A., Frumence E.,
RA   Sowdhamini R., Offmann B.;
RT   "Comparative genomics of odorant binding proteins in Anopheles gambiae,
RT   Aedes aegypti, and Culex quinquefasciatus.";
RL   Genome Biol. Evol. 5:163-180(2013).
CC   -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC       dendrites and are thought to aid in the capture and transport of
CC       hydrophobic odorants into and through this fluid. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR   EMBL; AAAB01008807; EAU77642.1; -; Genomic_DNA.
DR   RefSeq; XP_001237096.1; XM_001237095.1.
DR   AlphaFoldDB; A0NBD9; -.
DR   SMR; A0NBD9; -.
DR   PaxDb; A0NBD9; -.
DR   GeneID; 4576378; -.
DR   KEGG; aga:AgaP_AGAP007283; -.
DR   VEuPathDB; VectorBase:AGAP007283; -.
DR   eggNOG; ENOG502TB1Q; Eukaryota.
DR   HOGENOM; CLU_1251594_0_0_1; -.
DR   InParanoid; A0NBD9; -.
DR   OMA; CRDSLAT; -.
DR   OrthoDB; 1406862at2759; -.
DR   PhylomeDB; A0NBD9; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005549; F:odorant binding; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   InterPro; IPR036728; PBP_GOBP_sf.
DR   SUPFAM; SSF47565; SSF47565; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Olfaction; Reference proteome; Secreted;
KW   Sensory transduction; Signal; Transport.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000255"
FT   CHAIN           29..212
FT                   /note="General odorant-binding protein 66"
FT                   /id="PRO_0000430406"
FT   DISULFID        64..85
FT                   /evidence="ECO:0000250"
FT   DISULFID        80..152
FT                   /evidence="ECO:0000250"
FT   DISULFID        130..162
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   212 AA;  23594 MW;  C1BD2275C23F8445 CRC64;
     MATTIARIGS ANWAKVLVLL WLVQLATAGE PNPACKTMPT VDKDNEDKCC DVPEMFPNET
     LNACMEEYQK SSKPPLQKSC EITTCVLKKQ SLIKSDNTVD KDKIKSYIKE MVKGSDEWKT
     LVEKAVLEEC LPLMDKDPSN VLSKLKSSLG DCDPAPALTI ACAAAKFYVN CPAKDRTKSP
     MCDEWRTFLS KCSNSLEDLN AIFMVLENQK TR