ID   OBP67_ANOGA             Reviewed;         204 AA.
AC   Q5TXN1;
DT   01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=General odorant-binding protein 67;
DE   Flags: Precursor;
GN   Name=Obp67; ORFNames=AGAP012659;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=23292137; DOI=10.1093/gbe/evs131;
RA   Manoharan M., Ng Fuk Chong M., Vaitinadapoule A., Frumence E.,
RA   Sowdhamini R., Offmann B.;
RT   "Comparative genomics of odorant binding proteins in Anopheles gambiae,
RT   Aedes aegypti, and Culex quinquefasciatus.";
RL   Genome Biol. Evol. 5:163-180(2013).
CC   -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC       dendrites and are thought to aid in the capture and transport of
CC       hydrophobic odorants into and through this fluid. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR   EMBL; AAAB01007900; EAL42143.2; -; Genomic_DNA.
DR   RefSeq; XP_560792.4; XM_560792.4.
DR   AlphaFoldDB; Q5TXN1; -.
DR   SMR; Q5TXN1; -.
DR   STRING; 7165.AGAP012659-PA; -.
DR   GeneID; 3292264; -.
DR   KEGG; aga:AgaP_AGAP012659; -.
DR   VEuPathDB; VectorBase:AGAP012659; -.
DR   HOGENOM; CLU_125128_0_0_1; -.
DR   OMA; CIAECIM; -.
DR   OrthoDB; 1183407at2759; -.
DR   PhylomeDB; Q5TXN1; -.
DR   Proteomes; UP000007062; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005549; F:odorant binding; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   InterPro; IPR036728; PBP_GOBP_sf.
DR   SUPFAM; SSF47565; SSF47565; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Olfaction; Reference proteome; Secreted;
KW   Sensory transduction; Signal; Transport.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..204
FT                   /note="General odorant-binding protein 67"
FT                   /id="PRO_0000430407"
FT   DISULFID        57..85
FT                   /evidence="ECO:0000250"
FT   DISULFID        81..147
FT                   /evidence="ECO:0000250"
FT   DISULFID        128..157
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   204 AA;  22292 MW;  C2D163211D8481D9 CRC64;
     MNPVVCAFGV IFVVVTLELV VAHPGKDVLG CHNGTSITVD ECCAIPMLAN KTVIEKCKAA
     HPFKPPQNTD DKGPRGHPGE CIAECIMKGM GALKNEKVDG PAFRKAIEPV VKANPAFAKL
     LDDTVKQCHE SINVDSEFTR YVTKPVCKAD AKAFINCVYG TLFEQCPTNV WTQKDGCTQL
     KDKIKKGCAY FALRKHGGRR MRPT