ID   OBP69_ANOGA             Reviewed;         229 AA.
AC   F5HK49;
DT   01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=General odorant-binding protein 69;
DE   Flags: Precursor;
GN   Name=Obp69; ORFNames=AGAP013182;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=23292137; DOI=10.1093/gbe/evs131;
RA   Manoharan M., Ng Fuk Chong M., Vaitinadapoule A., Frumence E.,
RA   Sowdhamini R., Offmann B.;
RT   "Comparative genomics of odorant binding proteins in Anopheles gambiae,
RT   Aedes aegypti, and Culex quinquefasciatus.";
RL   Genome Biol. Evol. 5:163-180(2013).
CC   -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC       dendrites and are thought to aid in the capture and transport of
CC       hydrophobic odorants into and through this fluid. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR   EMBL; AAAB01008859; EGK96890.1; -; Genomic_DNA.
DR   RefSeq; XP_003436123.1; XM_003436075.1.
DR   AlphaFoldDB; F5HK49; -.
DR   STRING; 7165.AGAP013182-PA; -.
DR   PaxDb; F5HK49; -.
DR   PRIDE; F5HK49; -.
DR   GeneID; 11175636; -.
DR   KEGG; aga:AgaP_AGAP013182; -.
DR   VEuPathDB; VectorBase:AGAP013182; -.
DR   HOGENOM; CLU_1210682_0_0_1; -.
DR   OrthoDB; 1406632at2759; -.
DR   PhylomeDB; F5HK49; -.
DR   Proteomes; UP000007062; Chromosome 2R.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005549; F:odorant binding; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR   Gene3D; 1.10.238.20; -; 1.
DR   InterPro; IPR006170; PBP/GOBP.
DR   InterPro; IPR036728; PBP_GOBP_sf.
DR   Pfam; PF01395; PBP_GOBP; 1.
DR   SUPFAM; SSF47565; SSF47565; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Olfaction; Reference proteome; Secreted;
KW   Sensory transduction; Signal; Transport.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..229
FT                   /note="General odorant-binding protein 69"
FT                   /id="PRO_0000430409"
FT   DISULFID        66..106
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   229 AA;  26276 MW;  A24C6E8834216C83 CRC64;
     MDRLLLVLLS SASLLLTVYG IKHHIVTKSW SEAQSDCLQY LRVESPGRYL SHRYRDNQTS
     KQLIFCIILN LRIYDPTQNV LRLKAMGQFF NPDKTDTLYV NRTNACLLRV KVPPLVDSSE
     DSQLYSGVMG TLYEVFRCFY HCYGNINAIA PKLPPTVLEL EKIQQECARM VGVSERLLDG
     GLQLSSHPRY SKLPRCIMLR SGGSVDYLTH RNNSSRRFKL KKNVENDTL