ID   OBP70_ANOGA             Reviewed;         200 AA.
AC   Q7Q5L4;
DT   01-OCT-2014, integrated into UniProtKB/Swiss-Prot.
DT   07-DEC-2004, sequence version 2.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=General odorant-binding protein 70;
DE   Flags: Precursor;
GN   Name=Obp70; ORFNames=AGAP006368;
OS   Anopheles gambiae (African malaria mosquito).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC   Anophelinae; Anopheles.
OX   NCBI_TaxID=7165;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PEST;
RX   PubMed=12364791; DOI=10.1126/science.1076181;
RA   Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA   Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA   Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA   Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA   Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA   Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA   Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA   Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA   Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA   Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA   Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA   Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA   McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA   O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA   Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA   Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA   Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA   Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA   Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA   Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA   Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA   Collins F.H., Hoffman S.L.;
RT   "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL   Science 298:129-149(2002).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=23292137; DOI=10.1093/gbe/evs131;
RA   Manoharan M., Ng Fuk Chong M., Vaitinadapoule A., Frumence E.,
RA   Sowdhamini R., Offmann B.;
RT   "Comparative genomics of odorant binding proteins in Anopheles gambiae,
RT   Aedes aegypti, and Culex quinquefasciatus.";
RL   Genome Biol. Evol. 5:163-180(2013).
CC   -!- FUNCTION: Present in the aqueous fluid surrounding olfactory sensory
CC       dendrites and are thought to aid in the capture and transport of
CC       hydrophobic odorants into and through this fluid. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PBP/GOBP family. {ECO:0000305}.
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DR   EMBL; AAAB01008960; EAA11535.2; -; Genomic_DNA.
DR   RefSeq; XP_316397.2; XM_316397.3.
DR   AlphaFoldDB; Q7Q5L4; -.
DR   STRING; 7165.AGAP006368-PA; -.
DR   PaxDb; Q7Q5L4; -.
DR   GeneID; 1276977; -.
DR   KEGG; aga:AgaP_AGAP006368; -.
DR   VEuPathDB; VectorBase:AGAP006368; -.
DR   eggNOG; ENOG502S1QU; Eukaryota.
DR   HOGENOM; CLU_1512104_0_0_1; -.
DR   InParanoid; Q7Q5L4; -.
DR   OMA; EHGFFMA; -.
DR   OrthoDB; 1461542at2759; -.
DR   PhylomeDB; Q7Q5L4; -.
DR   Proteomes; UP000007062; Chromosome 2L.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005549; F:odorant binding; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.238.20; -; 1.
DR   InterPro; IPR006170; PBP/GOBP.
DR   InterPro; IPR036728; PBP_GOBP_sf.
DR   Pfam; PF01395; PBP_GOBP; 1.
DR   SUPFAM; SSF47565; SSF47565; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Olfaction; Reference proteome; Secreted;
KW   Sensory transduction; Signal; Transport.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..200
FT                   /note="General odorant-binding protein 70"
FT                   /id="PRO_0000430410"
FT   DISULFID        105..174
FT                   /evidence="ECO:0000250"
FT   DISULFID        152..183
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   200 AA;  22673 MW;  6414E8542C3CD266 CRC64;
     MRRQYSMWAS TVAVIACGSA LMLLHPVGAD APKKRCLTKP NVSKKVDMVI HQCQEEIKSS
     LIEDALKIFT AEHGQWHDRR KRDEGGLDFS HPTIVSHEDK WIAGCLMQCV YRKNNAIDKN
     GWPTLDGLVS LYTDGVNEQG YFMATLRGVD RCLKGTSKKY QIKRNDAAEN FEQCEVAFDV
     FDCISDMITD YCSGQMEDDH