ID   OBPA_CANAL              Reviewed;         433 AA.
AC   Q9UW25; A0A1D8PN99; Q59YI2;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Oxysterol-binding protein-like protein OBPa;
GN   Name=OBPA; OrderedLocusNames=CAALFM_C501770CA; ORFNames=CaO19.3198;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=10455055; DOI=10.1126/science.285.5431.1271;
RA   Hull C.M., Johnson A.D.;
RT   "Identification of a mating type-like locus in the asexual pathogenic yeast
RT   Candida albicans.";
RL   Science 285:1271-1275(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- MISCELLANEOUS: The C.albicans mating-type-like (MTL) locus contains, in
CC       addition to the genes for the regulatory proteins (MTLA1, MTLA2,
CC       MTLALPHA1 and MTLALPHA2), a and alpha idiomorphs of a
CC       phosphatidylinositol kinase (PIKA and PIKALPHA), a poly(A) polymerase
CC       (PAPA and PAPALPHA) and an oxysterol binding protein-like protein (OBPA
CC       and OBPALPHA).
CC   -!- SIMILARITY: Belongs to the OSBP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF167162; AAD51406.1; -; Genomic_DNA.
DR   EMBL; CP017627; AOW29608.1; -; Genomic_DNA.
DR   RefSeq; XP_714614.1; XM_709521.1.
DR   AlphaFoldDB; Q9UW25; -.
DR   SMR; Q9UW25; -.
DR   STRING; 237561.Q9UW25; -.
DR   GeneID; 3643764; -.
DR   KEGG; cal:CAALFM_C501770CA; -.
DR   CGD; CAL0000179350; OBPA.
DR   VEuPathDB; FungiDB:C5_01770C_A; -.
DR   HOGENOM; CLU_012334_4_2_1; -.
DR   InParanoid; Q9UW25; -.
DR   OMA; EISGKWS; -.
DR   OrthoDB; 1487815at2759; -.
DR   Proteomes; UP000000559; Chromosome 5.
DR   GO; GO:0032541; C:cortical endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR   GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR   GO; GO:0030011; P:maintenance of cell polarity; IBA:GO_Central.
DR   GO; GO:0034727; P:piecemeal microautophagy of the nucleus; IBA:GO_Central.
DR   GO; GO:0044011; P:single-species biofilm formation on inanimate substrate; IMP:CGD.
DR   InterPro; IPR037239; OSBP_sf.
DR   InterPro; IPR000648; Oxysterol-bd.
DR   InterPro; IPR018494; Oxysterol-bd_CS.
DR   PANTHER; PTHR10972; PTHR10972; 1.
DR   Pfam; PF01237; Oxysterol_BP; 1.
DR   SUPFAM; SSF144000; SSF144000; 1.
DR   PROSITE; PS01013; OSBP; 1.
PE   3: Inferred from homology;
KW   Lipid transport; Lipid-binding; Reference proteome; Transport.
FT   CHAIN           1..433
FT                   /note="Oxysterol-binding protein-like protein OBPa"
FT                   /id="PRO_0000100383"
SQ   SEQUENCE   433 AA;  49541 MW;  9088364356E50FFF CRC64;
     MGLTSKLEKL KLKELTGHEA AVKSNVVNGA DTDDTDDIDE MDNEGQSILM GIIAQLRPGM
     DLSRITLPTF ILEKKSMLER ITNFFQIPDM LLKANRTSDD VERFVSVLAW YLASWHIAPK
     AVKKPLNPVL GETFNCYWEN ISDDCSAYYI SEQVSHHPPK SSYFYLVPEA KIKVDGILIP
     KSRFLGNSSA AMMEGWAHLT LGEHENEVYE MNQPNVYCRG ILFGKMKMEL GDHMYVKCRK
     TGLEADIDFK TKGFISGTYD AIEGVIKNSK TSEVLYQITG KWNEVMEIKD LKTGKKRVLV
     DTKSSVPVKP RVRPLEEQGQ YESRKLWKPT IDALARRDHT VATEEKFAVE DEQRNLAKKR
     IDDGVEFHPK FFRPVNEKEV ELQDLEYVIY KKFDLKSNPE VLTDEVLSIA PILPGQKHDE
     KFEIPAFKKH EET