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OBP_BHV1C
ID   OBP_BHV1C               Reviewed;         859 AA.
AC   P52377;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Replication origin-binding protein;
DE   AltName: Full=OriBP;
DE            Short=OBP;
GN   Name=UL9;
OS   Bovine herpesvirus 1.1 (strain Cooper) (BoHV-1) (Infectious bovine
OS   rhinotracheitis virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10323;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7793062; DOI=10.1006/viro.1995.1321;
RA   Vlcek C., Benes V., Lu Z., Kutish G.F., Paces V., Rock D., Letchworth G.J.,
RA   Schwyzer M.;
RT   "Nucleotide sequence analysis of a 30-kb region of the bovine herpesvirus 1
RT   genome which exhibits a colinear gene arrangement with the UL21 to UL4
RT   genes of herpes simplex virus.";
RL   Virology 210:100-108(1995).
CC   -!- FUNCTION: Functions as a docking protein to recruit essential
CC       components of the viral replication machinery to viral DNA origins. In
CC       the presence of the major DNA-binding protein, opens dsDNA leading to a
CC       conformational change in the origin that facilitates DNA unwinding and
CC       subsequent replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with the major DNA-binding protein.
CC       Interacts with the helicase/primase component UL8 and the polymerase
CC       accessory protein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR   EMBL; Z48053; CAA88124.1; -; Genomic_DNA.
DR   EMBL; AJ004801; CAA06125.1; -; Genomic_DNA.
DR   PIR; S61246; S61246.
DR   RefSeq; NP_045350.1; NC_001847.1.
DR   GeneID; 1487403; -.
DR   KEGG; vg:1487403; -.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral process; IMP:AgBase.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Host nucleus;
KW   Nucleotide-binding.
FT   CHAIN           1..859
FT                   /note="Replication origin-binding protein"
FT                   /id="PRO_0000115867"
FT   DOMAIN          70..235
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   BINDING         83..90
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   859 AA;  92189 MW;  9EAC05A685160BC0 CRC64;
     MTATPGAAAD AVRVEGAGAC SDGGEEARYA SSASLARMLY GADLSERVRR RHPAVCVEHQ
     SGRPVALPSP LAADARRVTV VRAPMGSGKT TALLRWLGEA LGATDASVLV VSCRRSFTRT
     LHERLRDAAL PAFATYFDAR SYVMTGAAYR RLLVQVESLH RVDEELLGDY DILVLDEVMS
     TLAQLYSPTM GRLHRVDALL HRLLRRCPRI VAMDATVNAQ LVDLLAALRG AGSVHVVICD
     YASAGFLQRR CTVARRLGAR VLAARLKGDA EDGAEDGGAS FFTRLRARLE AGHNVCVFSS
     TVLFSELAAR FCLTFTPSVL VLNSTRPAEG DVSRWRDVRV LIYTTVITVG LSFDHSYFHA
     MFAYVKPMSH GPDMVSVYQS LGRIRSLVDN ELCVYFDSSA ARPEPVFTPM LLNHVVAEDG
     GWPATFSEVT NLLCCSFRAA CAPAFRGARG LALFPRFKYK HLFERCTLAS ASDSLNILHA
     LLENNRVGFQ LEALRSAHRR GILPLSRGRA RRRPAAAADL RALAAGIPSP VSAEGLAEHP
     AVAAFADKYL RAGGAPPAAL EELLRALNGP AARARFVNLA VLGGCLHVPA AAESLEVFAG
     IYRHYASGEV PVLTEAGAVE TAALAPGLRW KPTALFGLRR MARALGLLRR RGGGEADDVA
     DAAHGLTEPA IVELVGPPGG HDYAQCLLEI ARCNITPAGV MARGPVVAVA ARLSGRGFAQ
     GRGVGLGAAA HAVSVFKVIW EEVFGARLQK STQTFPGHAR VKNLRKHEIV ALLDLAGIDR
     AGRDTHRELY RLLMSHKARF ASPKYSLRLP KWGRLLGFAA RGPEPGPDAP PEASLEAALA
     RVPALHWPCA AGAVDFCAL
 
 
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