ID   OBP_EHV1B               Reviewed;         887 AA.
AC   P28947; Q6S6V1;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Replication origin-binding protein;
DE   AltName: Full=OriBP;
DE            Short=OBP;
GN   OrderedLocusNames=53;
OS   Equine herpesvirus 1 (strain Ab4p) (EHV-1) (Equine abortion virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=31520;
OH   NCBI_TaxID=9796; Equus caballus (Horse).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=1318606; DOI=10.1016/0042-6822(92)90706-u;
RA   Telford E.A.R., Watson M.S., McBride K., Davison A.J.;
RT   "The DNA sequence of equine herpesvirus-1.";
RL   Virology 189:304-316(1992).
CC   -!- FUNCTION: Functions as a docking protein to recruit essential
CC       components of the viral replication machinery to viral DNA origins. In
CC       the presence of the major DNA-binding protein, opens dsDNA leading to a
CC       conformational change in the origin that facilitates DNA unwinding and
CC       subsequent replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with the major DNA-binding protein.
CC       Interacts with the DNA helicase/primase complex-associated protein and
CC       the polymerase accessory protein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR   EMBL; AY665713; AAT67310.1; -; Genomic_DNA.
DR   PIR; H36800; WZBEE5.
DR   RefSeq; YP_053097.1; NC_001491.2.
DR   GeneID; 2948557; -.
DR   KEGG; vg:2948557; -.
DR   Proteomes; UP000001189; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Host nucleus;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..887
FT                   /note="Replication origin-binding protein"
FT                   /id="PRO_0000115868"
FT   DOMAIN          93..258
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   REGION          1..28
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         106..113
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   887 AA;  97276 MW;  E43727EDA58C76BA CRC64;
     MPSIGPIPTI PDEGSRGSSA TAAPRRAMAS YRDTTLGGRA EGVAFSAVED SYTSSVSLAR
     MLYGGDLEEW VRHTRPGVSL EIQSRAPVRF PPPNNPSSRR VTVVRAPMGS GKTTALLKWL
     GEALDAPDIS ALVVSCRRSF TRTLAKRFND AELPGFATYF TSTDYTMAGE PFRRLLVQIE
     SLHRVDDNLL NNYDILVLDE VMSTIGQLYS PTMVHLNKVD ALLTRLLKTC PRVIAMDATA
     NAQLVDFLAS ARGERSVHVI INSFAAPGFS QRDGTLLRTL GTDVLRAALG FVLVDDENGT
     KVMETDSRPI SARLREVNSA GFFGRLMDRL VAGRNVCVFS STVSFSEIVA RFCSQFTDSI
     LVLNSLRPSE DVAFWGGVRV LIYTTVVTVG LSFDTAHFHS MFAYVKPMSH GPDMVSVYQS
     LGRVRELIHN ELLVYVDSSG ARAEPIFTPM LLNHVVSRQG GWPAEFSQVT DALCCQFKAR
     CGPAYRTAST RGLALFVRFK YKHFFERCTL ASVGDSINIL YTLLESNQMR VAIEGCQFPL
     TAAGFCDFLQ DLRLDAYAAR KEIKQLRGPG GIAATPTEVF ENDDVAVFIQ KYLRPGVAHD
     EILALLVELN SPIVREQFVN VAVLGACLRL PAALESPEVF AGVYKHYASG VVPVISDAGA
     LESVSITPDV NVLARWDLYK SCTRHARDLA WDPSRGGSGL DMSEDFITNT LSADYNRFQS
     LLVEIAKCNV TPLEMLAAGA VRGVTTALSG RPKSRVPLSK GEHAVSLFKV LWEDVFGAKL
     AKSTQTFPGG VRVKNLRKDE IVALLESVNV NHSECKTHRE LYALLMCNRK LFAGPRYKLR
     APKWSRNLCF LELDNTGTCK TPLDAALADL APSAWPQVYG AVDFDAL