ID   OBP_GAHVM               Reviewed;         841 AA.
AC   Q9E6Q7;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Replication origin-binding protein;
DE            Short=OBP;
DE   AltName: Full=OriBP;
GN   Name=MDV021;
OS   Gallid herpesvirus 2 (strain Chicken/Md5/ATCC VR-987) (GaHV-2) (Marek's
OS   disease herpesvirus type 1).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Mardivirus.
OX   NCBI_TaxID=10389;
OH   NCBI_TaxID=9031; Gallus gallus (Chicken).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10933706; DOI=10.1128/jvi.74.17.7980-7988.2000;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Rock D.L., Kutish G.F.;
RT   "The genome of a very virulent Marek's disease virus.";
RL   J. Virol. 74:7980-7988(2000).
CC   -!- FUNCTION: Functions as a docking protein to recruit essential
CC       components of the viral replication machinery to viral DNA origins. In
CC       the presence of the major DNA-binding protein, opens dsDNA leading to a
CC       conformational change in the origin that facilitates DNA unwinding and
CC       subsequent replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with the major DNA-binding protein.
CC       Interacts with the DNA helicase/primase complex-associated protein and
CC       the polymerase accessory protein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR   EMBL; AF243438; AAG14201.1; -; Genomic_DNA.
DR   RefSeq; YP_001033937.1; NC_002229.3.
DR   PRIDE; Q9E6Q7; -.
DR   GeneID; 4811482; -.
DR   KEGG; vg:4811482; -.
DR   Proteomes; UP000008072; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Host nucleus;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..841
FT                   /note="Replication origin-binding protein"
FT                   /id="PRO_0000406507"
FT   DOMAIN          45..210
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   BINDING         58..65
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   841 AA;  95003 MW;  6C54491CFE2939C5 CRC64;
     MIDYASSASL SRMLYGEDLI DWIIKNRPGI TTERQSDGPV TFPSPLYPRT RNVLIVRAPM
     GSGKTTALMN WLQCILCNSN MSVLIVSCRR SFTNTLSEKI NRAGMSGFCT YLSSSDYIMR
     GREFSRLLVQ IESLHRVDSK LLDNYDIVIL DEIMSTIGQL FSPTMKHLCQ VDNILTSLLR
     YRPKIVAMDA TINTQLIDML AIMRGEENIH VIVGEYAASG FSRRSCTILR SLGTNILLSV
     MNEFKQLPSH TQPIFKQSTG VNGSLDISLH DRTFFSELTR RLEGGLNICL FSSTISFSEI
     VARFCLAYTD SVLVLNSTRN TPIDINSWSN YRVVIYTTVV TVGLSFNDSH FHSMFAYIKP
     TINGPEMVSV YQSLGRIRSL RLNEVLIYID ASGAGSEPVF TPMLLNHVIA NGGGWPTRFS
     QVTNMLCHNF RRDCIPTFRA ADALYIFPRF KYKHLFERCT LNNVSDSINI LHALLESNLI
     HVRFDGCDLQ LNAEAFCDFL VILRADSITA QRDMKTLRKN ATCPLPVEVD VIDSDAVACF
     VQKYLRPTVL ANDLTELLTK LAEPITREQF INITMLEACR ATPAALYSEA VFCRIYDYYA
     SGNIPIIGPS GTLDTTILTC DFNTSGRWDL YRVCCKWAEL LGINPLEGPN ADIDPTKLLH
     VMKDDYDIYA RSVLEIARCY LIDAQTALKR PVRATKCALS GIQNSHHSQP STQSHAVSLF
     KVTWEILFGL RLTKSTTTFP GRTKVKNLRK AEIEALLDGA GIDRTSCKTH KDLYTLLMKS
     KSLFRNMRYD IRRPKWYDLL RSRLDKELGI YHDLVDLESV LAEIPSALWP RVEGAVDFHR
     L