ID   OBP_HHV2H               Reviewed;         867 AA.
AC   P89432;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 2.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Replication origin-binding protein;
DE            Short=OBP;
DE   AltName: Full=OriBP;
GN   ORFNames=UL9;
OS   Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.
OX   NCBI_TaxID=10315;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9499055; DOI=10.1128/jvi.72.3.2010-2021.1998;
RA   Dolan A., Jamieson F.E., Cunningham C., Barnett B.C., McGeoch D.J.;
RT   "The genome sequence of herpes simplex virus type 2.";
RL   J. Virol. 72:2010-2021(1998).
CC   -!- FUNCTION: Functions as a docking protein to recruit essential
CC       components of the viral replication machinery to viral DNA origins. In
CC       the presence of the major DNA-binding protein, opens dsDNA leading to a
CC       conformational change in the origin that facilitates DNA unwinding and
CC       subsequent replication.
CC   -!- SUBUNIT: Homodimer. Interacts with the major DNA-binding protein ICP8.
CC       Interacts with the helicase/primase component UL8 and the polymerase
CC       accessory protein UL42 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR   EMBL; Z86099; CAB06769.2; -; Genomic_DNA.
DR   IntAct; P89432; 1.
DR   MINT; P89432; -.
DR   PRIDE; P89432; -.
DR   Proteomes; UP000001874; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Host nucleus;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..867
FT                   /note="Replication origin-binding protein"
FT                   /id="PRO_0000385140"
FT   DOMAIN          86..251
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         99..106
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   867 AA;  95799 MW;  099CE34F7AC4A24E CRC64;
     MNVATCTHQT HHAARAPGAT SAPGAASGDP LGARRPIGDD ECEQYTSSVS LARMLYGGDL
     AEWVPRVHPK TTIERQQHGP VTFPDASAPT ARCVTVVRAP MGSGKTTALI RWLGEAIHSP
     DTSVLVVSCR RSFTQTLATR FAESGLPDFV TYFSSTNYIM NDRPFHRLIV QVESLHRVGP
     NLLNNYDVLV LDEVMSTLGQ LYSPTMQQLG RVDALMLRLL RTCPRIIAMD ATANAQLVDF
     LCSLRGEKNV HVVIGEYAMP GFSARRCLFL PRLGPEVLQA ALRRRGPAGG APPPDAPPDA
     TFFGELEARL AGGDNVCIFS STVSFAEVVA RFCRQFTDRV LLLHSLTPPG DVTTWGRYRV
     VIYTTVVTVG LSFDPPHFDS MFAYVKPMNY GPDMVSVYQS LGRVRTLRKG ELLIYMDGSG
     ARSEPVFTPM LLNHVVSASG QWPAQFSQVT NLLCRRFKGR CDASHADAAQ ARGSRIYSKF
     RYKHYFERCT LACLADSLNI LHMLLTLNCM HVRFWGHDAA LTPRNFCLFL RGIHFDALRA
     QRDLRELRCQ DPDTSLSAQA AETEEVGLFV EKYLRPDVAP AEVVALMRGL NSLVGRTRFI
     YLVLLEACLR VPMAAHSSAI FRRLYDHYAT GVIPTINAAG ELELVALHPT LNVAPVWELF
     RLCSTMAACL QWDSMAGGSG RTFSPEDVLE LLNPHYDRYM QLVFELGHCN VTDGPLLSED
     AVKRVADALS GCPPRGSVSE TEHALSLFKI IWGELFGVQL AKSTQTFPGA GRVKNLTKRA
     IVELLDAHRI DHSACRTHRQ LYALLMAHKR EFAGARFKLR APAWGRCLRT HASGAQPNTD
     IILEAALSEL PTEAWPMMQG AVNFSTL