ID   OBP_HHV6U               Reviewed;         780 AA.
AC   P52378;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Replication origin-binding protein;
DE            Short=OBP;
GN   Name=U73; Synonyms=19R, HDRF0;
OS   Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B
OS   lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=10370;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=7747482; DOI=10.1006/viro.1995.1228;
RA   Gompels U.A., Nicholas J., Lawrence G.L., Jones M., Thomson B.J.,
RA   Martin M.E.D., Efstathiou S., Craxton M.A., Macaulay H.A.;
RT   "The DNA sequence of human herpesvirus-6: structure, coding content, and
RT   genome evolution.";
RL   Virology 209:29-51(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-703.
RX   PubMed=7844524; DOI=10.1099/0022-1317-76-1-147;
RA   Lawrence G.L., Nicholas J., Barrell B.G.;
RT   "Human herpesvirus 6 (strain U1102) encodes homologues of the conserved
RT   herpesvirus glycoprotein gM and the alphaherpesvirus origin-binding
RT   protein.";
RL   J. Gen. Virol. 76:147-152(1995).
CC   -!- FUNCTION: Probably involved in DNA replication. Binds the origin of
CC       replication (ori) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR   EMBL; X83413; CAA58365.1; -; Genomic_DNA.
DR   EMBL; M68963; AAA65581.1; -; Genomic_DNA.
DR   RefSeq; NP_042966.1; NC_001664.2.
DR   PRIDE; P52378; -.
DR   DNASU; 1487954; -.
DR   GeneID; 1487954; -.
DR   KEGG; vg:1487954; -.
DR   Proteomes; UP000009295; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..780
FT                   /note="Replication origin-binding protein"
FT                   /id="PRO_0000115870"
FT   DOMAIN          39..195
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   BINDING         52..59
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   780 AA;  89717 MW;  53F4B0E46C9BCB5F CRC64;
     MENRFQNDTL FSEWFGQSLS DVRFPDNVTV YSQADSAVSF ENVRQPIKLV RAAMGSGKTT
     ALIHFLKQVP RELSVLLISC RKTFAAEILH RFTLNGLKDF ELYCDITERQ INNRKVIVQI
     ESLHRLTENY DVLILDEIMS IIKQFYSKTM TKTKEVDCKF LSLIKNSSHV IAMDATLTRH
     VVEFFAAFKP DTQIALIRNT FVSAMFSNRI AYFCDTFFGK EFSFFARLED KLRWDKKLCL
     FCSTVLAAEY MYDLIRSRFP LKKVLLLTSK QGKCSSIESW IRYDVVIYTS VVTVGLSFEP
     VYFSSLFVYI QLAKGGPDMV SVFQSIGRVR RVIDEDIYIY MNPVLIRSYD PLAPIAIPPC
     SDWSVAEQSI ISESCIDFRG KCSGAHKYNF CSVLKSLFRY RHYIEKTTIT SLSDSLFLLC
     SLLCENSIKV DIVGNGFPMR KEVFLSFLQI LVEECHFIEK KITLPGDDMT FQEIISSRET
     IMNGDFYENG DQLLHKDYIT DMGKFRATFL SPGVDIFIAS DIVYDLKNES KRYVFVNVWL
     QKCVSAGVES TEIERVFCER IKCYMLPKSF LCDEYFVLGD ISGVYEWGML IDLAFLAEMI
     RKDLKLKSCT DTTTDISEDD LLLCAARRSS DILQIMQLVF TVHVQFFQKY SLQTLQLFNK
     LRGMRIVTGV FSIEKFSISI LRLFFKCAFN MTLSASRPRY IPGKAYRNLT KNDMENMLDN
     WEISRTNLKT CKELRKALTE ASRARRKQTI YKLQGSDISL SVSEVGVFGQ HASPGVCVSS