ID   OBP_HHV6Z               Reviewed;         780 AA.
AC   P52452;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Replication origin-binding protein;
DE            Short=OBP;
GN   Name=U73; Synonyms=CH6R;
OS   Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic
OS   virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=36351;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8634027; DOI=10.1007/bf01718406;
RA   Lindquester G.J., Inoue N., Allen R.D., Castelli J.W., Stamey F.R.,
RA   Dambaugh T.R., O'Brian J.J., Danovich R.M., Frenkel N., Pellett P.E.;
RT   "Restriction endonuclease mapping and molecular cloning of the human
RT   herpesvirus 6 variant B strain Z29 genome.";
RL   Arch. Virol. 141:367-379(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=10482553; DOI=10.1128/jvi.73.10.8040-8052.1999;
RA   Dominguez G., Dambaugh T.R., Stamey F.R., Dewhurst S., Inoue N.,
RA   Pellett P.E.;
RT   "Human herpesvirus 6B genome sequence: coding content and comparison with
RT   human herpesvirus 6A.";
RL   J. Virol. 73:8040-8052(1999).
CC   -!- FUNCTION: Probably involved in DNA replication. Binds the origin of
CC       replication (ori) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR   EMBL; AF157706; AAB06356.1; -; Genomic_DNA.
DR   PIR; T44218; T44218.
DR   RefSeq; NP_050252.1; NC_000898.1.
DR   PRIDE; P52452; -.
DR   DNASU; 1497073; -.
DR   GeneID; 1497073; -.
DR   KEGG; vg:1497073; -.
DR   Proteomes; UP000006930; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..780
FT                   /note="Replication origin-binding protein"
FT                   /id="PRO_0000115871"
FT   DOMAIN          39..195
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   BINDING         52..59
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   780 AA;  89554 MW;  1DE68504FA9624E6 CRC64;
     MENRFQNDTL FSEWFGQSLS DVRFPDNVTV YSQADSAVSF ENVRQPIKLV RAAMGSGKTT
     ALIHFLKQVP KELSVLLISC RKTFAAEILH RFTLNGLEDF ELYCDITERQ INNRKVIVQI
     ESLHRLTENY DVLILDEIMS IIKQFYSKTM TKTKEVDCKF LSLIKNSSHV IAMDATLTRH
     VVEFFAAFKP DTQIALIRNT FVSAMFSNRV AYFCDTFFGK EFSFFARLED KLRWDKKLCL
     FCSTVLAAEY MHDLIRSRFS LKKVLLLTSK QGKCSSIESW IRYDVVIYTS VVTVGLSFEP
     VYFSSLFVYI QLAKGGPDMV SIFQSIGRVR RVIDEDIYIY MNPVLIKSYD PLAPIAMPPC
     SDWSVAEQSI ISESCIDFRG KCSGAHKYNF CSVLKCLFRY RHYIEKTTIT SLSDSLFLLC
     SLLCENSIKV DIVGNGFPMR KEVFLSFLQI LVEECHFIEK KITLPGDNMT FQEIISSRET
     IMNGDFYENG NQLLHKDYIT DMGKFRATFL SPGVDIFIAS DIVSDLKNES KRYVFVNVWL
     QKCVSAGVES TRIERVFNER IKSYVLPKSF LCDEYFVLGD ISGVYEWGML IDLAFLAEMI
     RKDLKLKSCT DTTTDISEDD LLLCAARRSS DILQIMQLVF TVHVQFFQRY SLQTLQLFNK
     LRGMRIVTGV FSIEKFSISI LRLFFKCAFN MTLSASKPRY IPGKAYRNLT KNDLENMLDN
     WEISRTNLKT CKELRKALTE ASRARRKQTI YKLQGSDISL SVSEVGVFGQ HASPGVCVSS