ID   OBP_HHV7J               Reviewed;         787 AA.
AC   P52379;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Replication origin-binding protein;
DE            Short=OBP;
GN   Name=U73;
OS   Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Roseolovirus.
OX   NCBI_TaxID=57278;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8709220; DOI=10.1128/jvi.70.9.5975-5989.1996;
RA   Nicholas J.;
RT   "Determination and analysis of the complete nucleotide sequence of human
RT   herpesvirus.";
RL   J. Virol. 70:5975-5989(1996).
CC   -!- FUNCTION: Probably involved in DNA replication. Binds the origin of
CC       replication (ori) (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR   EMBL; U43400; AAC54734.1; -; Genomic_DNA.
DR   PIR; T41974; T41974.
DR   PRIDE; P52379; -.
DR   Proteomes; UP000009246; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..787
FT                   /note="Replication origin-binding protein"
FT                   /id="PRO_0000115872"
FT   DOMAIN          39..195
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   BINDING         52..59
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   787 AA;  90925 MW;  F5C4FB402801B1A0 CRC64;
     METQLQNDQL FLEWFGQNLL DCHFAQNVSV YLQDASMVHF KTFSEQIKII RAPMGSGKTS
     ALIEFLKTVS YIDSVLVISC RKTFAAELLN RFKKNDLNDF YLYSEIKERQ INKNKLIIQV
     ESLHRVTRNY HVLILDEIMS IIKQFYSKTM TKVKEVDAKL LTLIRNSTQI VAMDATVNRY
     VVDFFSLCMP HFKSALIINT FVSANFSNRS AYFCPTFIDG NLAFYGILKQ KLGLGKNICL
     FCSTVTSADF MSELLKTDFP DKKILLLTSK QGKCHSVESW INYNIVIYTS IVTVGLSFDF
     LHFSAMFVYI HLVKGGPDMV SVFQSMGRVR KVTDNEIFIY LNPALIQVPL SVSPISIPQC
     YDWTLFEKSI LQCSCMDFNK KCLSAQNYLS NSMIKQFFRI RHYIEKTTLL NLPDSLYLLC
     LLLDSNSIKV HIDGDVFPIA KEKFYAFTKM LVQGCHFFEK KKTDFVENTM TLKELFSNTN
     ITVNGEFYEL GNFQVHKDYI VNLNNFQNLF LKNDVDIFVI EEIMLTLKSE IRRFVFINAL
     LQKYVATGID VEKIKAFFKS RIKTFTLPEN YICSKFYLLS DISGVHECGM LMDVAFLAES
     IRADLNLQSC TDTQTDISED AILLCAARRS SEILRILQIV FTTHVQLFEK YNSYTLYLFN
     RLKGMQLNTW SLSIAKFSVS IIRMFFKCAF NMNLVKSKPR YIVGKPFRSL TKREIETLLD
     MWHVSRTNLK TYKELRKALT EASKKRQRKK IYKLLGHNIS SYISETGCLF QHADAGMCLS
     SGCLLRS