ID   OBP_PHOSU               Reviewed;         151 AA.
AC   S5ZYD3;
DT   03-JUL-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2013, sequence version 1.
DT   25-MAY-2022, entry version 21.
DE   RecName: Full=Odorant-binding protein {ECO:0000303|PubMed:21912180};
DE   AltName: Full=Lipocalin {ECO:0000303|PubMed:24993820};
DE   AltName: Allergen=Phod s 1.0101 {ECO:0000305};
DE   Flags: Fragment;
GN   Name=OBP {ECO:0000305};
OS   Phodopus sungorus (Striped hairy-footed hamster) (Djungarian hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Phodopus.
OX   NCBI_TaxID=10044 {ECO:0000312|EMBL:AGT28425.1};
RN   [1] {ECO:0000312|EMBL:AGT28425.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   ALLERGEN.
RC   TISSUE=Salivary gland {ECO:0000312|EMBL:AGT28425.1};
RX   PubMed=24993820; DOI=10.1074/jbc.m114.579060;
RA   Torres J.A., de Las Heras M., Maroto A.S., Vivanco F., Sastre J.,
RA   Pastor-Vargas C.;
RT   "Molecular and Immunological Characterization of the First Allergenic
RT   Lipocalin in Hamster: THE MAJOR ALLERGEN FROM SIBERIAN HAMSTER (PHODOPUS
RT   SUNGORUS).";
RL   J. Biol. Chem. 289:23382-23388(2014).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-8; 82-97 AND 102-114, IDENTIFICATION BY MASS
RP   SPECTROMETRY, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND ALLERGEN.
RX   PubMed=21912180; DOI=10.1159/000324956;
RA   Torres J.A., Pastor-Vargas C., de las Heras M., Vivanco F., Cuesta J.,
RA   Sastre J.;
RT   "An odorant-binding protein as a new allergen from Siberian hamster
RT   (Phodopus sungorus).";
RL   Int. Arch. Allergy Immunol. 157:109-112(2012).
CC   -!- FUNCTION: May act as a pheromone. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21912180,
CC       ECO:0000269|PubMed:24993820}.
CC   -!- TISSUE SPECIFICITY: Expressed in salivary glands, hair and urine.
CC       {ECO:0000269|PubMed:21912180, ECO:0000269|PubMed:24993820}.
CC   -!- ALLERGEN: Causes an allergic reaction in human (PubMed:24993820,
CC       PubMed:21912180). Binds to IgE in a patient bitten by Siberian hamster
CC       (PubMed:21912180). Binds to IgE in 100% of the 13 patients tested
CC       allergic to Siberian hamster. Causes degranulation of basophils
CC       (PubMed:24993820). {ECO:0000269|PubMed:21912180,
CC       ECO:0000269|PubMed:24993820}.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000255, ECO:0000305}.
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DR   EMBL; KF148615; AGT28425.1; -; mRNA.
DR   AlphaFoldDB; S5ZYD3; -.
DR   SMR; S5ZYD3; -.
DR   Allergome; 11963; Phod s 1.0101.
DR   Allergome; 845; Phod s 1.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002448; OBP-like.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01173; ODORANTBNDNG.
DR   SUPFAM; SSF50814; SSF50814; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           <1..151
FT                   /note="Odorant-binding protein"
FT                   /id="PRO_0000447621"
FT   DISULFID        38..42
FT                   /evidence="ECO:0000250|UniProtKB:P08937"
FT   DISULFID        57..149
FT                   /evidence="ECO:0000250|UniProtKB:P08937"
FT   CONFLICT        83
FT                   /note="Q -> K (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        96
FT                   /note="S -> N (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        108..110
FT                   /note="LIF -> EMY (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:AGT28425.1"
SQ   SEQUENCE   151 AA;  17168 MW;  3C1FC4B4E8ED7381 CRC64;
     NDYAELEGKW DTIAIAADND AKIKEEGPLR LYVRELYCNE DCSEMEVTFY VNANNQCSKT
     TVIGYKQADG TYRTQFEGDN RFQPVYATPE NIVFTSKNVD RAGQETNLIF VVGKSQPLTP
     EQHEKLVEFA HENNIPEENI HNVLATDTCP K