OBP_PIG
ID OBP_PIG Reviewed; 157 AA.
AC P81245;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 15-JUL-1998, sequence version 1.
DT 25-MAY-2022, entry version 112.
DE RecName: Full=Odorant-binding protein;
DE Short=OBP;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP PROTEIN SEQUENCE, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC TISSUE=Nasal mucosa;
RX PubMed=9915115; DOI=10.1093/chemse/23.6.689;
RA Paolini S., Scaloni A., Amoresano A., Marchese S., Napolitano E.,
RA Pelosi P.;
RT "Amino acid sequence, post-translational modifications, binding and
RT labelling of porcine odorant-binding protein.";
RL Chem. Senses 23:689-698(1998).
RN [2]
RP X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS).
RX PubMed=9609684; DOI=10.1021/bi980179e;
RA Spinelli S., Ramoni R., Grolli S., Bonicel J., Cambillau C., Tegoni M.;
RT "The structure of the monomeric porcine odorant binding protein sheds light
RT on the domain swapping mechanism.";
RL Biochemistry 37:7913-7918(1998).
CC -!- FUNCTION: This protein is found in nasal epithelium and it binds a wide
CC variety of chemical odorants.
CC -!- SUBUNIT: Monomer.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC {ECO:0000305}.
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DR PDB; 1A3Y; X-ray; 2.25 A; A/B=9-157.
DR PDB; 1DZJ; X-ray; 2.00 A; A/B=1-157.
DR PDB; 1DZK; X-ray; 1.48 A; A/B=1-157.
DR PDB; 1DZM; X-ray; 1.93 A; A/B=1-157.
DR PDB; 1DZP; X-ray; 1.83 A; A/B=1-157.
DR PDB; 1E00; X-ray; 1.83 A; A/B=1-157.
DR PDB; 1E02; X-ray; 2.15 A; A/B=1-157.
DR PDB; 1E06; X-ray; 2.12 A; A/B=1-157.
DR PDB; 1HQP; X-ray; 2.30 A; A=1-157.
DR PDBsum; 1A3Y; -.
DR PDBsum; 1DZJ; -.
DR PDBsum; 1DZK; -.
DR PDBsum; 1DZM; -.
DR PDBsum; 1DZP; -.
DR PDBsum; 1E00; -.
DR PDBsum; 1E02; -.
DR PDBsum; 1E06; -.
DR PDBsum; 1HQP; -.
DR AlphaFoldDB; P81245; -.
DR SMR; P81245; -.
DR iPTMnet; P81245; -.
DR PaxDb; P81245; -.
DR PeptideAtlas; P81245; -.
DR eggNOG; ENOG502TDZD; Eukaryota.
DR HOGENOM; CLU_094061_4_2_1; -.
DR EvolutionaryTrace; P81245; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; P81245; SS.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR002345; Lipocalin.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR002448; OBP-like.
DR PANTHER; PTHR11430; PTHR11430; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR01173; ODORANTBNDNG.
DR SUPFAM; SSF50814; SSF50814; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Direct protein sequencing; Disulfide bond; Olfaction;
KW Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW Sensory transduction; Transport.
FT CHAIN 1..157
FT /note="Odorant-binding protein"
FT /id="PRO_0000201025"
FT MOD_RES 1
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:9915115"
FT DISULFID 63..155
FT STRAND 13..15
FT /evidence="ECO:0007829|PDB:1E02"
FT STRAND 17..24
FT /evidence="ECO:0007829|PDB:1DZK"
FT HELIX 26..28
FT /evidence="ECO:0007829|PDB:1DZK"
FT STRAND 38..45
FT /evidence="ECO:0007829|PDB:1DZK"
FT TURN 46..49
FT /evidence="ECO:0007829|PDB:1DZK"
FT STRAND 50..59
FT /evidence="ECO:0007829|PDB:1DZK"
FT STRAND 62..73
FT /evidence="ECO:0007829|PDB:1DZK"
FT HELIX 74..76
FT /evidence="ECO:0007829|PDB:1DZK"
FT STRAND 77..93
FT /evidence="ECO:0007829|PDB:1DZK"
FT STRAND 95..105
FT /evidence="ECO:0007829|PDB:1DZK"
FT STRAND 111..122
FT /evidence="ECO:0007829|PDB:1DZK"
FT HELIX 126..138
FT /evidence="ECO:0007829|PDB:1DZK"
FT HELIX 143..145
FT /evidence="ECO:0007829|PDB:1DZK"
FT STRAND 146..149
FT /evidence="ECO:0007829|PDB:1DZK"
FT HELIX 150..152
FT /evidence="ECO:0007829|PDB:1DZK"
SQ SEQUENCE 157 AA; 17708 MW; 8E406B01AEA768A9 CRC64;
QEPQPEQDPF ELSGKWITSY IGSSDLEKIG ENAPFQVFMR SIEFDDKESK VYLNFFSKEN
GICEEFSLIG TKQEGNTYDV NYAGNNKFVV SYASETALII SNINVDEEGD KTIMTGLLGK
GTDIEDQDLE KFKEVTRENG IPEENIVNII ERDDCPA
