ID   OBP_PSHV1               Reviewed;         880 AA.
AC   Q6UDH3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Replication origin-binding protein;
DE            Short=OBP;
DE   AltName: Full=OriBP;
GN   Name=UL9;
OS   Psittacid herpesvirus 1 (isolate Amazon parrot/-/97-0001/1997) (PsHV-1)
OS   (Pacheco's disease virus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Iltovirus.
OX   NCBI_TaxID=670426;
OH   NCBI_TaxID=152276; Amazona oratrix (yellow-headed parrot).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16873243; DOI=10.1128/jvi.00134-06;
RA   Thureen D.R., Keeler C.L. Jr.;
RT   "Psittacid herpesvirus 1 and infectious laryngotracheitis virus:
RT   Comparative genome sequence analysis of two avian alphaherpesviruses.";
RL   J. Virol. 80:7863-7872(2006).
CC   -!- FUNCTION: Functions as a docking protein to recruit essential
CC       components of the viral replication machinery to viral DNA origins. In
CC       the presence of the major DNA-binding protein, opens dsDNA leading to a
CC       conformational change in the origin that facilitates DNA unwinding and
CC       subsequent replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with the major DNA-binding protein.
CC       Interacts with the DNA helicase/primase complex-associated protein and
CC       the polymerase accessory protein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR   EMBL; AY372243; AAQ73737.1; -; Genomic_DNA.
DR   RefSeq; NP_944431.1; NC_005264.1.
DR   PRIDE; Q6UDH3; -.
DR   GeneID; 2657002; -.
DR   KEGG; vg:2657002; -.
DR   Proteomes; UP000006840; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Host nucleus;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..880
FT                   /note="Replication origin-binding protein"
FT                   /id="PRO_0000406803"
FT   DOMAIN          60..225
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   REGION          260..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         73..80
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   880 AA;  98512 MW;  EF93D4B961236ACB CRC64;
     MCSETGTGVP ERNGCADSFS PSVMIARKLY GCDLCERLLT NPRMAGMSLD RQHGHPITFP
     LPIRTKPVLV ARAPMGSGKT TALIDWLTAF LDSEDKSAVI VSCRRSFTNS LSRRFQRDGL
     TGFTTYLDSD QYVLTEAAHR RLLVQLESLQ RISDSLLDRY DVLVVDEVMS IVAQFFSPTM
     RRLRLVDSMF TSLLRRCRHV IAMDATVNAT LVELLAELRG AENVHVVVSD FVSRGFANRE
     CVVMSSLGAA LPASMVRYAP PAGDESREAS ASQPPPHDSS NEPCAPEITD ADIESTEGSF
     FHELHVRLLQ GENVCVFSST LAFSRIVAFF CAEVLSPDAV LLLNSTSPPV DTSDWSRYKV
     VVYTTVVTVG LSFDDSHFHT MFAFVKPSIH GPDMMAVYQA MGRVRSLIRD RLFMYMDVSS
     ANEGPTFTPM LLNAEIGSAT AWPPEILIPA NTMCLRFKDR CSSALLDHHR ALFSRFKTKH
     YLERSTLTSA NDSFSLLHTL LANNKIAVRM RGDRPDAPAS AILVEDFGRF LSRLRTDAFS
     NRRFLRRITY AIEEAASAMR ERVALRNPTA EETVMMLAEN QAARSCMERF FGLRGAVDDY
     GEPIIALMKD MGDVPLVAAR LVNAAVIEAG CACSAGEWYV VDLAAEHASH GSSEFDKWMN
     YYLDEPLVSL KRGRPEEVQI PIQPGIRGRT ALLRACVNVA RQIGWRPTTW NDDAELEAAD
     VERAMATAIE AGLGKFALEY MRLNFTEPSW LTGPIRNLQR FLGARKRHAA HGIGPSEQRK
     ESPEICIFRT LWAELFGVRI LKSQRTFPGT TRVKNLRKEH LKALLDRIEV RYPESSTHKQ
     LYGLLRENQY RFSNSPKLLL RTPDWMRQLS GNRPQAEQAP