ID   OBP_RAT                 Reviewed;         172 AA.
AC   P08937;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   03-AUG-2022, entry version 141.
DE   RecName: Full=Odorant-binding protein;
DE            Short=OBP;
DE   Flags: Precursor;
GN   Name=Obp1f;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 16-31.
RX   PubMed=3388043; DOI=10.1126/science.3388043;
RA   Pevsner J., Reed R.R., Feinstein P.G., Snyder S.H.;
RT   "Molecular cloning of odorant-binding protein: member of a ligand carrier
RT   family.";
RL   Science 241:336-339(1988).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 17-172, AND DISULFIDE BONDS.
RX   PubMed=19390145; DOI=10.1107/s090744490900420x;
RA   White S.A., Briand L., Scott D.J., Borysik A.J.;
RT   "Structure of rat odorant-binding protein OBP1 at 1.6 A resolution.";
RL   Acta Crystallogr. D 65:403-410(2009).
CC   -!- FUNCTION: This protein is found in nasal epithelium and it binds a wide
CC       variety of chemical odorants.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the calycin superfamily. Lipocalin family.
CC       {ECO:0000305}.
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DR   EMBL; J03093; AAA41736.1; -; mRNA.
DR   PIR; A28713; A28713.
DR   RefSeq; NP_620258.1; NM_138903.1.
DR   PDB; 3FIQ; X-ray; 1.60 A; A/B=17-172.
DR   PDBsum; 3FIQ; -.
DR   AlphaFoldDB; P08937; -.
DR   SMR; P08937; -.
DR   STRING; 10116.ENSRNOP00000064887; -.
DR   PaxDb; P08937; -.
DR   GeneID; 192267; -.
DR   KEGG; rno:192267; -.
DR   CTD; 192267; -.
DR   RGD; 621639; Obp1f.
DR   VEuPathDB; HostDB:ENSRNOG00000062551; -.
DR   eggNOG; ENOG502TDZD; Eukaryota.
DR   HOGENOM; CLU_094061_4_2_1; -.
DR   InParanoid; P08937; -.
DR   OMA; PLRCYNR; -.
DR   OrthoDB; 1357921at2759; -.
DR   TreeFam; TF338197; -.
DR   EvolutionaryTrace; P08937; -.
DR   PRO; PR:P08937; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000049515; Expressed in liver and 2 other tissues.
DR   Genevisible; P08937; RN.
DR   GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR   GO; GO:0005549; F:odorant binding; IDA:RGD.
DR   GO; GO:0036094; F:small molecule binding; IEA:InterPro.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   Gene3D; 2.40.128.20; -; 1.
DR   InterPro; IPR012674; Calycin.
DR   InterPro; IPR002345; Lipocalin.
DR   InterPro; IPR022272; Lipocalin_CS.
DR   InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR   InterPro; IPR002448; OBP-like.
DR   PANTHER; PTHR11430; PTHR11430; 1.
DR   Pfam; PF00061; Lipocalin; 1.
DR   PRINTS; PR01173; ODORANTBNDNG.
DR   SUPFAM; SSF50814; SSF50814; 1.
DR   PROSITE; PS00213; LIPOCALIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Direct protein sequencing; Disulfide bond; Olfaction;
KW   Reference proteome; Secreted; Sensory transduction; Signal; Transport.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000269|PubMed:3388043"
FT   CHAIN           16..172
FT                   /note="Odorant-binding protein"
FT                   /id="PRO_0000017936"
FT   DISULFID        60..64
FT                   /evidence="ECO:0000269|PubMed:19390145"
FT   DISULFID        79..170
FT                   /evidence="ECO:0000269|PubMed:19390145"
FT   HELIX           25..28
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   STRAND          33..41
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   HELIX           42..44
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   STRAND          54..60
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   HELIX           62..64
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   STRAND          66..75
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   STRAND          78..88
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   STRAND          94..109
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   STRAND          111..121
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   STRAND          127..137
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   HELIX           141..153
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   HELIX           158..160
FT                   /evidence="ECO:0007829|PDB:3FIQ"
FT   HELIX           165..167
FT                   /evidence="ECO:0007829|PDB:3FIQ"
SQ   SEQUENCE   172 AA;  19699 MW;  9DAFFDEF67F724DD CRC64;
     MVKFLLIVLA LGVSCAHHEN LDISPSEVNG DWRTLYIVAD NVEKVAEGGS LRAYFQHMEC
     GDECQELKII FNVKLDSECQ THTVVGQKHE DGRYTTDYSG RNYFHVLKKT DDIIFFHNVN
     VDESGRRQCD LVAGKREDLN KAQKQELRKL AEEYNIPNEN TQHLVPTDTC NQ