ID   OBP_VZVD                Reviewed;         835 AA.
AC   P09299;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Replication origin-binding protein;
DE            Short=OBP;
DE   AltName: Full=OriBP;
GN   ORFNames=ORF51;
OS   Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Alphaherpesvirinae; Varicellovirus.
OX   NCBI_TaxID=10338;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=3018124; DOI=10.1099/0022-1317-67-9-1759;
RA   Davison A.J., Scott J.E.;
RT   "The complete DNA sequence of varicella-zoster virus.";
RL   J. Gen. Virol. 67:1759-1816(1986).
CC   -!- FUNCTION: Functions as a docking protein to recruit essential
CC       components of the viral replication machinery to viral DNA origins. In
CC       the presence of the major DNA-binding protein, opens dsDNA leading to a
CC       conformational change in the origin that facilitates DNA unwinding and
CC       subsequent replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with the major DNA-binding protein.
CC       Interacts with the helicase/primase component 52 and the polymerase
CC       accessory protein (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR   EMBL; X04370; CAA27933.1; -; Genomic_DNA.
DR   PIR; G27344; WZBE51.
DR   PRIDE; P09299; -.
DR   Proteomes; UP000002602; Genome.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0039686; P:bidirectional double-stranded viral DNA replication; IDA:UniProtKB.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003450; Replication_origin-bd.
DR   Pfam; PF02399; Herpes_ori_bp; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE   3: Inferred from homology;
KW   ATP-binding; DNA replication; DNA-binding; Host nucleus;
KW   Nucleotide-binding; Reference proteome.
FT   CHAIN           1..835
FT                   /note="Replication origin-binding protein"
FT                   /id="PRO_0000115873"
FT   DOMAIN          54..215
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT   BINDING         67..74
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ   SEQUENCE   835 AA;  94375 MW;  A71F5877ACF386FB CRC64;
     MSPNTGESNA AVYASSTQLA RALYGGDLVS WIKHTHPGIS LELQLDVPVK LIKPGMSQTR
     PVTVVRAPMG SGKTTALLEW LQHALKADIS VLVVSCRRSF TQTLIQRFND AGLSGFVTYL
     TSETYIMGFK RLIVQLESLH RVSSEAIDSY DVLILDEVMS VIGQLYSPTM RRLSAVDSLL
     YRLLNRCSQI IAMDATVNSQ FIDLISGLRG DENIHTIVCT YAGVGFSGRT CTILRDMGID
     TLVRVIKRSP EHEDVRTIHQ LRGTFFDELA LRLQCGHNIC IFSSTLSFSE LVAQFCAIFT
     DSILILNSTR PLCNVNEWKH FRVLVYTTVV TVGLSFDMAH FHSMFAYIKP MSYGPDMVSV
     YQSLGRVRLL LLNEVLMYVD GSRTRCGPLF SPMLLNFTIA NKFQWFPTHT QITNKLCCAF
     RQRCANAFTR SNTHLFSRFK YKHLFERCSL WSLADSINIL QTLLASNQIL VVLDGMGPIT
     DVSPVQFCAF IHDLRHSANA VASCMRSLRQ DNDSCLTDFG PSGFMADNIT AFMEKYLMES
     INTEEQIKVF KALACPIEQP RLVNTAILGA CIRIPEALEA FDVFQKIYTH YASGWFPVLD
     KTGEFSIATI TTAPNLTTHW ELFRRCAYIA KTLKWNPSTE GCVTQVLDTD INTLFNQHGD
     SLAQLIFEVM RCNVTDAKII LNRPVWRTTG FLDGCHNQCF RPIPTKHEYN IALFRLIWEQ
     LFGARVTKST QTFPGSTRVK NLKKKDLETL LDSINVDRSA CRTYRQLYNL LMSQRHSFSQ
     QRYKITAPAW ARHVYFQAHQ MHLAPHAEAM LQLALSELSP GSWPRINGAV NFESL