ID   OBRG_BOVIN              Reviewed;         131 AA.
AC   Q3SYT0;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Leptin receptor gene-related protein;
DE   AltName: Full=Endospanin-1;
DE   AltName: Full=OB-R gene-related protein;
DE            Short=OB-RGRP;
GN   Name=LEPROT; Synonyms=LEPR, OBR;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates leptin receptor (LEPR) cell surface
CC       expression, and thus decreases response to leptin/LEP. Negatively
CC       regulates growth hormone (GH) receptor cell surface expression in
CC       liver. May play a role in liver resistance to GH during periods of
CC       reduced nutrient availability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LEPR. Interacts with RAB13 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR   EMBL; BC103409; AAI03410.1; -; mRNA.
DR   RefSeq; NP_001029913.1; NM_001034741.1.
DR   AlphaFoldDB; Q3SYT0; -.
DR   STRING; 9913.ENSBTAP00000007762; -.
DR   PaxDb; Q3SYT0; -.
DR   GeneID; 613665; -.
DR   KEGG; bta:613665; -.
DR   CTD; 54741; -.
DR   eggNOG; KOG2174; Eukaryota.
DR   HOGENOM; CLU_134810_2_2_1; -.
DR   InParanoid; Q3SYT0; -.
DR   OrthoDB; 1642378at2759; -.
DR   TreeFam; TF313689; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0060400; P:negative regulation of growth hormone receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007262; Vps55/LEPROT.
DR   PANTHER; PTHR12050; PTHR12050; 1.
DR   Pfam; PF04133; Vps55; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Leptin receptor gene-related protein"
FT                   /id="PRO_0000397878"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   131 AA;  14228 MW;  46A0CD41C8FF6697 CRC64;
     MAGVKALVAL SFSGAIGLTF LMLGCALEDY GVYWPLFVLI FHAISPIPHF IAKRATYDSD
     ATSSACRELA YFFTTGIVVS AFGFPVILAR VSVIKWGACG LVLAGNAVIF LTIQGFFLVF
     GRGDDFSWEQ W