ID   OBRG_CHICK              Reviewed;         131 AA.
AC   Q5ZJD9;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Leptin receptor gene-related protein;
DE   AltName: Full=Endospanin-1;
DE   AltName: Full=OB-R gene-related protein;
DE            Short=OB-RGRP;
GN   Name=LEPROT; Synonyms=LEPR-GRP; ORFNames=RCJMB04_19b9;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Involved in protein trafficking. May be involved in the down-
CC       regulation of membrane protein levels (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR   EMBL; AJ720495; CAG32154.1; -; mRNA.
DR   RefSeq; NP_001007959.1; NM_001007958.1.
DR   AlphaFoldDB; Q5ZJD9; -.
DR   STRING; 9031.ENSGALP00000017973; -.
DR   PaxDb; Q5ZJD9; -.
DR   Ensembl; ENSGALT00000017995; ENSGALP00000017973; ENSGALG00000011047.
DR   GeneID; 424699; -.
DR   KEGG; gga:424699; -.
DR   CTD; 54741; -.
DR   VEuPathDB; HostDB:geneid_424699; -.
DR   eggNOG; KOG2174; Eukaryota.
DR   GeneTree; ENSGT00390000006503; -.
DR   HOGENOM; CLU_134810_2_2_1; -.
DR   InParanoid; Q5ZJD9; -.
DR   OMA; GGDEFSW; -.
DR   PhylomeDB; Q5ZJD9; -.
DR   TreeFam; TF313689; -.
DR   PRO; PR:Q5ZJD9; -.
DR   Proteomes; UP000000539; Chromosome 8.
DR   Bgee; ENSGALG00000011047; Expressed in colon and 13 other tissues.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0060400; P:negative regulation of growth hormone receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007262; Vps55/LEPROT.
DR   PANTHER; PTHR12050; PTHR12050; 1.
DR   Pfam; PF04133; Vps55; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Leptin receptor gene-related protein"
FT                   /id="PRO_0000397880"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   131 AA;  14389 MW;  9E3AD16A8EA5D727 CRC64;
     MAGIKALVGL SFSGAIGLTF LMLGCALEYY GVYWPMFVLI FYFICPIPHF IARRVSDDSD
     AASSACRELA YFFTTGIVVS AFGFPIILAR VEAIKWGACG LVLAGNAVIF LTILGFFLVF
     GRGDDFSWEQ W