ID   OBRG_DANRE              Reviewed;         130 AA.
AC   Q561T9;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Leptin receptor gene-related protein;
DE   AltName: Full=Endospanin-1;
DE   AltName: Full=OB-R gene-related protein;
DE            Short=OB-RGRP;
GN   Name=leprot; Synonyms=lepr-grp; ORFNames=zgc:112430;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in protein trafficking. May be involved in the down-
CC       regulation of membrane protein levels (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR   EMBL; BC093304; AAH93304.1; -; mRNA.
DR   RefSeq; NP_001017787.1; NM_001017787.1.
DR   AlphaFoldDB; Q561T9; -.
DR   STRING; 7955.ENSDARP00000103077; -.
DR   PaxDb; Q561T9; -.
DR   GeneID; 550484; -.
DR   KEGG; dre:550484; -.
DR   CTD; 54741; -.
DR   ZFIN; ZDB-GENE-050417-314; leprot.
DR   eggNOG; KOG2174; Eukaryota.
DR   InParanoid; Q561T9; -.
DR   OrthoDB; 1642378at2759; -.
DR   PhylomeDB; Q561T9; -.
DR   PRO; PR:Q561T9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0060400; P:negative regulation of growth hormone receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR007262; Vps55/LEPROT.
DR   PANTHER; PTHR12050; PTHR12050; 1.
DR   Pfam; PF04133; Vps55; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..130
FT                   /note="Leptin receptor gene-related protein"
FT                   /id="PRO_0000397883"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   130 AA;  14130 MW;  B9D09B49FB69CF69 CRC64;
     MAGIKALVAL SFSGALGLTF LLLGCALEQF GQYWPMFVLI FYILSPIPNL IARRHADDTE
     SSNACRELAY FLTTGIVVSA YGLPVVLARK AVIQWGAAGL VMAGNCVIFL TILGFFLIFG
     GGDDFSWEQW