ID   OBRG_MELGA              Reviewed;         131 AA.
AC   Q5PSV5;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   04-JAN-2005, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Leptin receptor gene-related protein;
DE   AltName: Full=Endospanin-1;
DE   AltName: Full=OB-R gene-related protein;
DE            Short=OB-RGRP;
GN   Name=LEPROT; Synonyms=LEPR-GRP;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=14662306; DOI=10.1016/s1096-4959(03)00260-4;
RA   Richards M.P., Poch S.M.;
RT   "Molecular cloning and expression of the turkey leptin receptor gene.";
RL   Comp. Biochem. Physiol. 136:833-847(2003).
CC   -!- FUNCTION: Involved in protein trafficking. May be involved in the down-
CC       regulation of membrane protein levels (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Widely expressed, including in liver, duodenum,
CC       kidney, pancreas, lung, spleen and brain.
CC       {ECO:0000269|PubMed:14662306}.
CC   -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR   EMBL; AY826977; AAV80477.1; -; mRNA.
DR   RefSeq; NP_001290101.1; NM_001303172.1.
DR   AlphaFoldDB; Q5PSV5; -.
DR   Ensembl; ENSMGAT00000013333; ENSMGAP00000012441; ENSMGAG00000011858.
DR   GeneID; 100303675; -.
DR   KEGG; mgp:100303675; -.
DR   CTD; 54741; -.
DR   GeneTree; ENSGT00390000006503; -.
DR   HOGENOM; CLU_134810_2_2_1; -.
DR   InParanoid; Q5PSV5; -.
DR   OMA; GGDEFSW; -.
DR   OrthoDB; 1642378at2759; -.
DR   TreeFam; TF313689; -.
DR   Proteomes; UP000001645; Chromosome 10.
DR   Bgee; ENSMGAG00000011858; Expressed in testis and 17 other tissues.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007262; Vps55/LEPROT.
DR   PANTHER; PTHR12050; PTHR12050; 1.
DR   Pfam; PF04133; Vps55; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Leptin receptor gene-related protein"
FT                   /id="PRO_0000397881"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   131 AA;  14389 MW;  9E3AD16A8EA5D727 CRC64;
     MAGIKALVGL SFSGAIGLTF LMLGCALEYY GVYWPMFVLI FYFICPIPHF IARRVSDDSD
     AASSACRELA YFFTTGIVVS AFGFPIILAR VEAIKWGACG LVLAGNAVIF LTILGFFLVF
     GRGDDFSWEQ W