ID   OBRG_PIG                Reviewed;         131 AA.
AC   B9TRX0; D0G775;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Leptin receptor gene-related protein;
DE   AltName: Full=Endospanin-1;
DE   AltName: Full=OB-R gene-related protein;
DE            Short=OB-RGRP;
GN   Name=LEPROT; Synonyms=LEPR, OBR;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Landrace;
RA   Matsumoto T., Okumura N., Uenishi H., Hamasima N.;
RT   "Cloning of porcine genes involved in fat metabolism.";
RL   Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kim J.H., Jeon J.T.;
RT   "Construction of a radiation hybrid map on pig chromosome 6.";
RL   Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Negatively regulates leptin receptor (LEPR) cell surface
CC       expression, and thus decreases response to leptin/LEP. Negatively
CC       regulates growth hormone (GH) receptor cell surface expression in
CC       liver. May play a role in liver resistance to GH during periods of
CC       reduced nutrient availability (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LEPR. Interacts with RAB13 (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAI48028.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AB529857; BAI48028.1; ALT_FRAME; mRNA.
DR   EMBL; EU189935; ABZ03971.1; -; mRNA.
DR   RefSeq; NP_001138860.1; NM_001145388.1.
DR   AlphaFoldDB; B9TRX0; -.
DR   STRING; 9823.ENSSSCP00000004117; -.
DR   PaxDb; B9TRX0; -.
DR   PeptideAtlas; B9TRX0; -.
DR   PRIDE; B9TRX0; -.
DR   Ensembl; ENSSSCT00005033418; ENSSSCP00005020372; ENSSSCG00005021089.
DR   Ensembl; ENSSSCT00035074765; ENSSSCP00035030364; ENSSSCG00035056016.
DR   Ensembl; ENSSSCT00065053913; ENSSSCP00065023447; ENSSSCG00065039432.
DR   GeneID; 100270821; -.
DR   KEGG; ssc:100270821; -.
DR   CTD; 54741; -.
DR   eggNOG; KOG2174; Eukaryota.
DR   InParanoid; B9TRX0; -.
DR   OMA; GGDEFSW; -.
DR   OrthoDB; 1642378at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0060400; P:negative regulation of growth hormone receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:2000009; P:negative regulation of protein localization to cell surface; IEA:Ensembl.
DR   GO; GO:0046426; P:negative regulation of receptor signaling pathway via JAK-STAT; IEA:Ensembl.
DR   InterPro; IPR007262; Vps55/LEPROT.
DR   PANTHER; PTHR12050; PTHR12050; 1.
DR   Pfam; PF04133; Vps55; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Leptin receptor gene-related protein"
FT                   /id="PRO_0000397879"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   131 AA;  14198 MW;  26D5770A22B49767 CRC64;
     MAGVKALVAL SFSGAIGLTF LMLGCALEDY GVYWPLFVLV FHALSPIPHF IAKRATYDSD
     ATSSACRELA YFFTTGIVVS AFGFPVILAR VAVIKWGACG LVLAGNAVIF LTIQGFFLVF
     GRGDDFSWEQ W