ID   OBRG_RAT                Reviewed;         131 AA.
AC   Q9JLS8;
DT   21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Leptin receptor gene-related protein;
DE   AltName: Full=Endospanin-1;
DE   AltName: Full=OB-R gene-related protein;
DE            Short=OB-RGRP;
GN   Name=Leprot; Synonyms=Lepr, Obr;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Lindell K., Carlsson L.M.S., Carlsson B.;
RT   "OB-receptor gene related protein (OB-RGRP) in the rat.";
RL   Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=19907080; DOI=10.1172/jci34997;
RA   Touvier T., Conte-Auriol F., Briand O., Cudejko C., Paumelle R., Caron S.,
RA   Bauge E., Rouille Y., Salles J.P., Staels B., Bailleul B.;
RT   "LEPROT and LEPROTL1 cooperatively decrease hepatic growth hormone action
RT   in mice.";
RL   J. Clin. Invest. 119:3830-3838(2009).
RN   [4]
RP   INTERACTION WITH RAB13.
RX   PubMed=23772379; DOI=10.1016/j.fob.2013.01.004;
RA   Hirvonen M.J., Bueki K.G., Sun Y., Mulari M.T., Haerkoenen P.L.,
RA   Vaeaenaenen K.H.;
RT   "Novel interaction of Rab13 and Rab8 with endospanins.";
RL   FEBS Open Bio 3:83-88(2013).
CC   -!- FUNCTION: Negatively regulates leptin receptor (LEPR) cell surface
CC       expression, and thus decreases response to leptin (By similarity).
CC       Negatively regulates growth hormone (GH) receptor cell surface
CC       expression in liver. May play a role in liver resistance to GH during
CC       periods of reduced nutrient availability. {ECO:0000250,
CC       ECO:0000269|PubMed:19907080}.
CC   -!- SUBUNIT: Interacts with LEPR (By similarity). Interacts with RAB13.
CC       {ECO:0000250, ECO:0000269|PubMed:23772379}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
CC   -!- INDUCTION: Down-regulated by insulin. {ECO:0000269|PubMed:19907080}.
CC   -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
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DR   EMBL; AF139209; AAF63411.1; -; mRNA.
DR   EMBL; BC062003; AAH62003.1; -; mRNA.
DR   RefSeq; NP_064484.1; NM_020099.2.
DR   AlphaFoldDB; Q9JLS8; -.
DR   IntAct; Q9JLS8; 2.
DR   STRING; 10116.ENSRNOP00000007859; -.
DR   PaxDb; Q9JLS8; -.
DR   GeneID; 56766; -.
DR   KEGG; rno:56766; -.
DR   UCSC; RGD:621034; rat.
DR   CTD; 54741; -.
DR   RGD; 621034; Leprot.
DR   VEuPathDB; HostDB:ENSRNOG00000050849; -.
DR   eggNOG; KOG2174; Eukaryota.
DR   HOGENOM; CLU_134810_2_2_1; -.
DR   InParanoid; Q9JLS8; -.
DR   OMA; GGDEFSW; -.
DR   OrthoDB; 1642378at2759; -.
DR   PhylomeDB; Q9JLS8; -.
DR   PRO; PR:Q9JLS8; -.
DR   Proteomes; UP000002494; Chromosome 5.
DR   Bgee; ENSRNOG00000050849; Expressed in spleen and 20 other tissues.
DR   Genevisible; Q9JLS8; RN.
DR   GO; GO:0005768; C:endosome; ISO:RGD.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; ISO:RGD.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; ISO:RGD.
DR   GO; GO:0032511; P:late endosome to vacuole transport via multivesicular body sorting pathway; IBA:GO_Central.
DR   GO; GO:0060400; P:negative regulation of growth hormone receptor signaling pathway; ISO:RGD.
DR   GO; GO:2000009; P:negative regulation of protein localization to cell surface; ISO:RGD.
DR   GO; GO:0046426; P:negative regulation of receptor signaling pathway via JAK-STAT; ISO:RGD.
DR   InterPro; IPR007262; Vps55/LEPROT.
DR   PANTHER; PTHR12050; PTHR12050; 1.
DR   Pfam; PF04133; Vps55; 1.
PE   1: Evidence at protein level;
KW   Endosome; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..131
FT                   /note="Leptin receptor gene-related protein"
FT                   /id="PRO_0000215196"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        32..52
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   131 AA;  14320 MW;  58EBEC50B01DEA81 CRC64;
     MAGVKALVAL SFSGAIGLTF LMLGCALEDY GVYWPLFVLI FYVISPIPYF IAKRVTYDSD
     ATSSACRELA YFFTTGIVVS AFGFPVILAR VAVIKWGACG LVLAGNAVIF LTIQGFFLVF
     GRGDDFSWEQ W