ID   OBRG_TAKRU              Reviewed;         130 AA.
AC   B3Y064;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Leptin receptor gene-related protein;
DE   AltName: Full=Endospanin-1;
DE   AltName: Full=OB-R gene-related protein;
DE            Short=OB-RGRP;
GN   Name=leprot; Synonyms=lepr-grp;
OS   Takifugu rubripes (Japanese pufferfish) (Fugu rubripes).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Tetraodontiformes; Tetradontoidea; Tetraodontidae; Takifugu.
OX   NCBI_TaxID=31033;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Pituitary;
RX   PubMed=18582469; DOI=10.1016/j.ygcen.2008.06.003;
RA   Kurokawa T., Murashita K., Suzuki T., Uji S.;
RT   "Genomic characterization and tissue distribution of leptin receptor and
RT   leptin receptor overlapping transcript genes in the pufferfish, Takifugu
RT   rubripes.";
RL   Gen. Comp. Endocrinol. 158:108-114(2008).
CC   -!- FUNCTION: Involved in protein trafficking. May be involved in the down-
CC       regulation of membrane protein levels (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:18582469}.
CC   -!- SIMILARITY: Belongs to the OB-RGRP/VPS55 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB385664; BAG67080.1; -; mRNA.
DR   RefSeq; NP_001129621.1; NM_001136149.1.
DR   AlphaFoldDB; B3Y064; -.
DR   STRING; 31033.ENSTRUP00000003786; -.
DR   GeneID; 100191072; -.
DR   KEGG; tru:100191072; -.
DR   CTD; 54741; -.
DR   eggNOG; KOG2174; Eukaryota.
DR   InParanoid; B3Y064; -.
DR   OrthoDB; 1642378at2759; -.
DR   Proteomes; UP000005226; Unplaced.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR007262; Vps55/LEPROT.
DR   PANTHER; PTHR12050; PTHR12050; 1.
DR   Pfam; PF04133; Vps55; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..130
FT                   /note="Leptin receptor gene-related protein"
FT                   /id="PRO_0000397882"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        68..88
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   130 AA;  13992 MW;  747F9CBD803FA38E CRC64;
     MAGIKALVGL SFSGAMGLTL LLLGCALEQY GIYWPLFVLI FYVLSPIPTF ISRRLSDGGS
     SSNACRELAY FLTTGIVVSS FGLPIVLART ATIQWGACGL VMTGNAVIFL TIFGFFVVFG
     GGDEFSWEQW