ID   OC90_CAVPO              Reviewed;          51 AA.
AC   P81869;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Otoconin-90 {ECO:0000303|PubMed:9860971};
DE            Short=Oc90 {ECO:0000303|PubMed:9860971};
DE   Flags: Fragment;
GN   Name=OC90;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=9860971; DOI=10.1073/pnas.95.26.15345;
RA   Wang Y., Kowalski P.E., Thalmann I., Ornitz D.M., Mager D.L., Thalmann R.;
RT   "Otoconin-90, the mammalian otoconial matrix protein, contains two domains
RT   of homology to secretory phospholipase A2.";
RL   Proc. Natl. Acad. Sci. U.S.A. 95:15345-15350(1998).
CC   -!- FUNCTION: Major protein of the otoconia, a calcium carbonate structure
CC       in the saccule and utricle of the ear. Together with OTOL1, acts as a
CC       scaffold for otoconia biomineralization: sequesters calcium and forms
CC       interconnecting fibrils between otoconia that are incorporated into the
CC       calcium crystal structure. Together with OTOL1, modulates calcite
CC       crystal morphology and growth kinetics. It is unlikely that this
CC       protein has phospholipase A2 activity. {ECO:0000250|UniProtKB:Q9Z0L3}.
CC   -!- SUBUNIT: Interacts with OTOL1. {ECO:0000250|UniProtKB:Q9Z0L3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9860971}.
CC   -!- SIMILARITY: Belongs to the phospholipase A2 family. {ECO:0000305}.
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DR   AlphaFoldDB; P81869; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0045299; P:otolith mineralization; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   Calcium; Direct protein sequencing; Metal-binding; Reference proteome;
KW   Secreted.
FT   CHAIN           1..>51
FT                   /note="Otoconin-90"
FT                   /id="PRO_0000161727"
FT   NON_TER         51
SQ   SEQUENCE   51 AA;  5645 MW;  C8A803B856970AA0 CRC64;
     HALDTPHFPQ ELTSALSKNI CITFFSGMFK NVESVAEIFD SLGPSFKQDQ A