ID   A28_LSDVN               Reviewed;         140 AA.
AC   Q8JTR0;
DT   29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   29-MAR-2004, sequence version 2.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Envelope protein A28 homolog;
DE   AltName: Full=Protein LSDV118;
GN   OrderedLocusNames=LSDV118, LD118, LW118;
OS   Lumpy skin disease virus (isolate Bovine/Kenya/Neethling 2490/1958) (LSDV)
OS   (Lumpy skin disease virus (isolate NI-2490)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Capripoxvirus.
OX   NCBI_TaxID=376849;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Neethling 2490;
RX   PubMed=11435593; DOI=10.1128/jvi.75.15.7122-7130.2001;
RA   Tulman E.R., Afonso C.L., Lu Z., Zsak L., Kutish G.F., Rock D.L.;
RT   "Genome of lumpy skin disease virus.";
RL   J. Virol. 75:7122-7130(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate Neethling vaccine LW 1959, and
RC   Isolate Neethling Warmbaths LW;
RX   PubMed=12827464; DOI=10.1007/s00705-003-0102-0;
RA   Kara P.D., Afonso C.L., Wallace D.B., Kutish G.F., Abolnik C., Lu Z.,
RA   Vreede F.T., Taljaard L.C.F., Zsak A., Viljoen G.J., Rock D.L.;
RT   "Comparative sequence analysis of the South African vaccine strain and two
RT   virulent field isolates of Lumpy skin disease virus.";
RL   Arch. Virol. 148:1335-1356(2003).
CC   -!- FUNCTION: Envelope protein required for virus entry into host cell and
CC       for cell-cell fusion (syncytium formation). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Virion membrane {ECO:0000305}; Single-pass type
CC       II membrane protein {ECO:0000305}. Note=Component of the intracellular
CC       mature virion (IMV) membrane. {ECO:0000250}.
CC   -!- PTM: Contains two intramolecular disulfide bonds. They are created by
CC       the viral disulfide bond formation pathway, a poxvirus-specific pathway
CC       that operates on the cytoplasmic side of the MV membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae A28 protein family.
CC       {ECO:0000305}.
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DR   EMBL; AF325528; AAK85079.1; -; Genomic_DNA.
DR   EMBL; AF409137; AAN02686.1; -; Genomic_DNA.
DR   EMBL; AF409138; AAN02843.1; -; Genomic_DNA.
DR   RefSeq; NP_150552.1; NC_003027.1.
DR   GeneID; 921573; -.
DR   KEGG; vg:921573; -.
DR   Proteomes; UP000126568; Genome.
DR   Proteomes; UP000127252; Genome.
DR   Proteomes; UP000156762; Genome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0039663; P:membrane fusion involved in viral entry into host cell; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   InterPro; IPR007664; Poxvirus_A28.
DR   Pfam; PF04584; Pox_A28; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Fusion of virus membrane with host membrane; Late protein;
KW   Membrane; Signal-anchor; Transmembrane; Transmembrane helix;
KW   Viral envelope protein; Viral penetration into host cytoplasm; Virion;
KW   Virus entry into host cell.
FT   CHAIN           1..140
FT                   /note="Envelope protein A28 homolog"
FT                   /id="PRO_0000099292"
FT   TRANSMEM        1..21
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        22..140
FT                   /note="Virion surface"
FT                   /evidence="ECO:0000255"
FT   VARIANT         10
FT                   /note="I -> V (in strain: Isolate Neethling vaccine LW
FT                   1959)"
SQ   SEQUENCE   140 AA;  16203 MW;  AB22777F3A99094A CRC64;
     MNAITIFFII LSTVAVCIII FQLYSIYLNY DNIKEFNSAH SAFEFSKSVN TLSLDRTIKD
     PNDDIYDPKQ KWRCVKLDND YVSVSMFGFK SNGSEIRKFK NLESCIDYTF SQSTHSDIKN
     PCILQNGIKS KECIFLKSMF