ID   OCA3_SCHPO              Reviewed;         282 AA.
AC   O60110;
DT   04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 3.
DT   25-MAY-2022, entry version 117.
DE   RecName: Full=TPR repeat protein oca3;
DE   AltName: Full=Overexpression-mediated cell cycle arrest protein 3;
GN   Name=oca3; ORFNames=SPBC15C4.01c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [2]
RP   FUNCTION.
RX   PubMed=12237855; DOI=10.1002/yea.902;
RA   Tallada V.A., Daga R.R., Palomeque C., Garzon A., Jimenez J.;
RT   "Genome-wide search of Schizosaccharomyces pombe genes causing
RT   overexpression-mediated cell cycle defects.";
RL   Yeast 19:1139-1151(2002).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
CC   -!- FUNCTION: May be involved in cell cycle regulation.
CC       {ECO:0000269|PubMed:12237855}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}. Nucleus
CC       {ECO:0000269|PubMed:16823372}. Note=Localizes also to the barrier
CC       septum.
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DR   EMBL; CU329671; CAA18435.2; -; Genomic_DNA.
DR   RefSeq; NP_595921.2; NM_001021829.2.
DR   AlphaFoldDB; O60110; -.
DR   SMR; O60110; -.
DR   BioGRID; 276418; 2.
DR   STRING; 4896.SPBC15C4.01c.1; -.
DR   MaxQB; O60110; -.
DR   PaxDb; O60110; -.
DR   PRIDE; O60110; -.
DR   EnsemblFungi; SPBC15C4.01c.1; SPBC15C4.01c.1:pep; SPBC15C4.01c.
DR   GeneID; 2539872; -.
DR   KEGG; spo:SPBC15C4.01c; -.
DR   PomBase; SPBC15C4.01c; oca3.
DR   VEuPathDB; FungiDB:SPBC15C4.01c; -.
DR   eggNOG; KOG3060; Eukaryota.
DR   HOGENOM; CLU_052388_1_2_1; -.
DR   InParanoid; O60110; -.
DR   OMA; YILTCAE; -.
DR   PhylomeDB; O60110; -.
DR   PRO; PR:O60110; -.
DR   Proteomes; UP000002485; Chromosome II.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0072546; C:EMC complex; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045048; P:protein insertion into ER membrane; IC:PomBase.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR039856; EMC2-like.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12760; PTHR12760; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   4: Predicted;
KW   Cell cycle; Cytoplasm; Nucleus; Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..282
FT                   /note="TPR repeat protein oca3"
FT                   /id="PRO_0000353838"
FT   REPEAT          16..50
FT                   /note="TPR 1"
FT   REPEAT          71..104
FT                   /note="TPR 2"
FT   REPEAT          139..172
FT                   /note="TPR 3"
FT   REPEAT          174..211
FT                   /note="TPR 4"
SQ   SEQUENCE   282 AA;  32823 MW;  D26D2A5EAF90F3F8 CRC64;
     MSNSILKVPD QNPQEIVALF SQQEAYAKLG KYKDEIWDVY QKVFIAALTT GETVLAKKCW
     NRLNDRFHKS PRVEGLYGMF LEATASEKDA MSYYNSKLSE DPTHTVIYKR KLALLRSMGQ
     TKECIQGLIN YLDTFYNDLE AWAELADIYV SVEAFESAIF CYEEMVLLQP FEPRLFARLG
     DLYFVLAQSN ATNYWFSLKH YCRSVEICEE YFHGWFGISK CCQQLLELSR TELKRLLSKV
     NEKISDTFPD TESVRQLYQL SLKKSDLFAQ KQPKLKALLE QC