ID   OCA4_YEAST              Reviewed;         362 AA.
AC   P25366; D6VR95;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 144.
DE   RecName: Full=Protein OCA4;
DE   AltName: Full=Oxidant-induced cell-cycle arrest protein 4;
GN   Name=OCA4; OrderedLocusNames=YCR095C; ORFNames=YCR131, YCR95C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=1574125; DOI=10.1038/357038a0;
RA   Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA   Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA   Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA   Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA   Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA   Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA   Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA   Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA   Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA   Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA   Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA   Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA   Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA   Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA   Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA   Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA   Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA   Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA   Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA   Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA   Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA   Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA   Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA   Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA   Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA   Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA   Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA   Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA   Sgouros J.G.;
RT   "The complete DNA sequence of yeast chromosome III.";
RL   Nature 357:38-46(1992).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-113.
RX   PubMed=1574927; DOI=10.1002/yea.320080307;
RA   Sor F., Cheret G., Fabre F., Faye G., Fukuhara H.;
RT   "Sequence of the HMR region on chromosome III of Saccharomyces
RT   cerevisiae.";
RL   Yeast 8:215-222(1992).
RN   [4]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [5]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [6]
RP   FUNCTION.
RX   PubMed=14671320; DOI=10.1073/pnas.2536857100;
RA   Kushner D.B., Lindenbach B.D., Grdzelishvili V.Z., Noueiry A.O., Paul S.M.,
RA   Ahlquist P.;
RT   "Systematic, genome-wide identification of host genes affecting replication
RT   of a positive-strand RNA virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:15764-15769(2003).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=17287358; DOI=10.1073/pnas.0607084104;
RA   Chi A., Huttenhower C., Geer L.Y., Coon J.J., Syka J.E.P., Bai D.L.,
RA   Shabanowitz J., Burke D.J., Troyanskaya O.G., Hunt D.F.;
RT   "Analysis of phosphorylation sites on proteins from Saccharomyces
RT   cerevisiae by electron transfer dissociation (ETD) mass spectrometry.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:2193-2198(2007).
RN   [8]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=18205808; DOI=10.1111/j.1567-1364.2007.00349.x;
RA   Fong C.S., Temple M.D., Alic N., Chiu J., Durchdewald M., Thorpe G.W.,
RA   Higgins V.J., Dawes I.W.;
RT   "Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the
RT   involvement of the SWI6 transcription factor.";
RL   FEMS Yeast Res. 8:386-399(2008).
RN   [9]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=18845848; DOI=10.1534/genetics.108.092577;
RA   Addinall S.G., Downey M., Yu M., Zubko M.K., Dewar J., Leake A.,
RA   Hallinan J., Shaw O., James K., Wilkinson D.J., Wipat A., Durocher D.,
RA   Lydall D.;
RT   "A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied
RT   cellular processes influencing telomere capping in Saccharomyces
RT   cerevisiae.";
RL   Genetics 180:2251-2266(2008).
RN   [10]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA   Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT   "A multidimensional chromatography technology for in-depth phosphoproteome
RT   analysis.";
RL   Mol. Cell. Proteomics 7:1389-1396(2008).
RN   [11]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19779198; DOI=10.1126/science.1172867;
RA   Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT   "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT   into evolution.";
RL   Science 325:1682-1686(2009).
CC   -!- FUNCTION: Required for replication of Brome mosaic virus (BMV).
CC       {ECO:0000269|PubMed:14671320}.
CC   -!- INTERACTION:
CC       P25366; P38738: OCA5; NbExp=4; IntAct=EBI-22021, EBI-24355;
CC   -!- DISRUPTION PHENOTYPE: Exhibits an absence of G1 checkpoint in response
CC       to linoleic acid hydroperoxide (LoaOOH) treatment. Rescues the
CC       temperature sensitivity of CDC13-1 mutant.
CC       {ECO:0000269|PubMed:18205808, ECO:0000269|PubMed:18845848}.
CC   -!- MISCELLANEOUS: Present with 5370 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
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DR   EMBL; X59720; CAA42250.1; -; Genomic_DNA.
DR   EMBL; BK006937; DAA07564.1; -; Genomic_DNA.
DR   PIR; S19511; S19511.
DR   RefSeq; NP_010019.1; NM_001178801.1.
DR   AlphaFoldDB; P25366; -.
DR   SMR; P25366; -.
DR   BioGRID; 31067; 207.
DR   DIP; DIP-5005N; -.
DR   IntAct; P25366; 9.
DR   MINT; P25366; -.
DR   STRING; 4932.YCR095C; -.
DR   iPTMnet; P25366; -.
DR   MaxQB; P25366; -.
DR   PaxDb; P25366; -.
DR   PRIDE; P25366; -.
DR   EnsemblFungi; YCR095C_mRNA; YCR095C; YCR095C.
DR   GeneID; 850457; -.
DR   KEGG; sce:YCR095C; -.
DR   SGD; S000000691; OCA4.
DR   VEuPathDB; FungiDB:YCR095C; -.
DR   eggNOG; KOG1572; Eukaryota.
DR   GeneTree; ENSGT00940000176301; -.
DR   HOGENOM; CLU_036633_0_0_1; -.
DR   InParanoid; P25366; -.
DR   OMA; FQRDLWE; -.
DR   BioCyc; YEAST:G3O-29389-MON; -.
DR   PRO; PR:P25366; -.
DR   Proteomes; UP000002311; Chromosome III.
DR   RNAct; P25366; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   Gene3D; 3.90.190.10; -; 1.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR004861; Siw14-like.
DR   Pfam; PF03162; Y_phosphatase2; 1.
DR   SUPFAM; SSF52799; SSF52799; 1.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..362
FT                   /note="Protein OCA4"
FT                   /id="PRO_0000202581"
SQ   SEQUENCE   362 AA;  41647 MW;  B927AE5248F4B51F CRC64;
     MLVPPANFGI AEEGIYRCSK VETLNLSFLE TLNLKTAIFI GGQEPSKFFK DFFTRSSIKW
     IVLRMSDFSA AAVPVKSSSV SNANLYSNNN STLSLQEEKK KSTANGSQNS TTGDPVIQEE
     LAYHLTDNDD LMLIKSTCLK RTFKTLLNVD NYNVLLVDKT ALVIGILRKI QKWNIASIIN
     EYRLFSGKNR NYFAETFLEI INIEIEQEKD NKTIVDNKAK KLPLENNRTH SIEYKANSGK
     LIRVNEDDLC REPEVPQRLL TLINQIETKV KNNKVLQVSG VLGDDLKKTS SDLGIFGHRY
     RLAFNKKENG DYGYYKARGK DNVKIRIPCD SELPDWFRFQ RDLWEKENVP EEHHFYREHI
     FT