OCA5_KLULA
ID OCA5_KLULA Reviewed; 530 AA.
AC Q6CS52;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 77.
DE RecName: Full=Oxidant-induced cell-cycle arrest protein 5;
GN Name=OCA5; OrderedLocusNames=KLLA0D03861g;
OS Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX NCBI_TaxID=284590;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the OCA5 family. {ECO:0000305}.
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DR EMBL; CR382124; CAH00333.1; -; Genomic_DNA.
DR RefSeq; XP_453237.1; XM_453237.1.
DR AlphaFoldDB; Q6CS52; -.
DR STRING; 28985.XP_453237.1; -.
DR PRIDE; Q6CS52; -.
DR EnsemblFungi; CAH00333; CAH00333; KLLA0_D03861g.
DR GeneID; 2892864; -.
DR KEGG; kla:KLLA0_D03861g; -.
DR eggNOG; ENOG502QVXN; Eukaryota.
DR HOGENOM; CLU_028817_0_0_1; -.
DR InParanoid; Q6CS52; -.
DR OMA; LGPDIFW; -.
DR Proteomes; UP000000598; Chromosome D.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR Pfam; PF00566; RabGAP-TBC; 1.
DR SMART; SM00164; TBC; 1.
DR SUPFAM; SSF47923; SSF47923; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Reference proteome.
FT CHAIN 1..530
FT /note="Oxidant-induced cell-cycle arrest protein 5"
FT /id="PRO_0000408212"
FT DOMAIN 58..319
FT /note="Rab-GAP TBC"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 467..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 62300 MW; 6A90ED32BC5E94A4 CRC64;
MPLKPSSSHS ERKNRLHLHA SSRNAKQQEW NRELVTLFIK LLNENDHASL ALVARNAGVP
PQLRPAVWPT LLKYHPMVIS PNIMSNTLVF KDDENEAELR YFPEDRSEED ISELMENDLN
KYFQVRNSVP VSAEIQEIKS LLKECVWQFL RKWNKICKYE SGLIWIALGL AEWCPLKNND
DLVLAGRKHH HHNSCLRHLY EEYPIPDELL NQLPDTEFDF AAIYERLVLV LFHAPALDEK
PDKSNYHLLK SGNLNQQSQL FFKVFAKTLP ELYQPITDEG ALQGSKKATW LYWWIKCCGC
RVLHRQDRGR VWDVLLGWRP RPESINYYLE YNHKSFESIY PPELKLSSEI FHKICKCEHD
EFWFPDLMSL RLGQNGLNQD EDVIRELIRR NKYGDDGHTT ETQENEIPYS LLNPHAELLF
IYVAIMQHNE FKLLEFEETE ITEFLNNVPL ISKFDDYNFK KMYEDDDISG SSTDTDESNA
SGIRPSSSNH MMIEVGTDDK TAHSFDDIYQ QAGDIWRNWA WQEMEEFIEE