ID   OCA5_LACTC              Reviewed;         566 AA.
AC   C5DHP1;
DT   03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Oxidant-induced cell-cycle arrest protein 5;
GN   Name=OCA5; OrderedLocusNames=KLTH0E05918g;
OS   Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284)
OS   (Yeast) (Kluyveromyces thermotolerans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Lachancea.
OX   NCBI_TaxID=559295;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 56472 / CBS 6340 / NRRL Y-8284;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the OCA5 family. {ECO:0000305}.
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DR   EMBL; CU928169; CAR23302.1; -; Genomic_DNA.
DR   RefSeq; XP_002553739.1; XM_002553693.1.
DR   AlphaFoldDB; C5DHP1; -.
DR   STRING; 559295.C5DHP1; -.
DR   EnsemblFungi; CAR23302; CAR23302; KLTH0E05918g.
DR   GeneID; 8291892; -.
DR   KEGG; lth:KLTH0E05918g; -.
DR   eggNOG; ENOG502QVXN; Eukaryota.
DR   HOGENOM; CLU_028817_0_0_1; -.
DR   InParanoid; C5DHP1; -.
DR   OMA; LGPDIFW; -.
DR   OrthoDB; 467078at2759; -.
DR   Proteomes; UP000002036; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..566
FT                   /note="Oxidant-induced cell-cycle arrest protein 5"
FT                   /id="PRO_0000408213"
FT   DOMAIN          50..336
FT                   /note="Rab-GAP TBC"
FT   REGION          120..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          500..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..515
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   566 AA;  65415 MW;  C146248AFB55F98A CRC64;
     MTDRKTLVHS HLHWRNVKRK HWQKDLVAKV VELIKVGDHD ALALVARTAG IPPQLRKHVW
     PVLLKFHPMV VSPNIMSNTL VWDSQHQKWH YHPEIRSEDE IRDQMAHDLG KYFHKRTSAG
     KRAQSAASGP GAAPGGDLSP LPPGQQRVVA ALQQCILKFL QKWAQFFKYE SGLAWIALAL
     AEWCPLDGGE DVLPGKRHGA PVNLYHEYFL PEEIRDQLPS ESEFAFDELF ERLVLVILHS
     PDIPKAERLA RAESEMTSVL QYYPVISGGD LSFQCQLFFK VFSVILPELY QPVSDEETLR
     PSKKTNWMYW WFKCSGARVF HKQDRARIWD TLLGWRPHPR SLNFYLNYNS KLFDHLYSTR
     TSSALDSEFF HKICKYGHDA FWFPDLDSLS LGSQDLKCDF QVLSELVRRN KYDNSDDELE
     ITPKNNGTVG SKIKKGVEIP FSLLDPHVQL IFIYMAILQQ HEFKLLEFEE AEISEFFNNV
     PSLSRADDHN YRSLYEEEIE SRSVSSSETE PEDLFKRPGS SASTPHMLIE VGDDDKASKS
     FDDLYNLAGD IWRKWIWREL EDNAGT