ID   OCA5_YEAST              Reviewed;         679 AA.
AC   P38738; D3DKT9;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Oxidant-induced cell-cycle arrest protein 5;
GN   Name=OCA5; OrderedLocusNames=YHL029C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=8091229; DOI=10.1126/science.8091229;
RA   Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z.,
RA   Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T.,
RA   Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P., Louis E.J.,
RA   Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L.,
RA   St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P.,
RA   Waterston R., Wilson R., Vaudin M.;
RT   "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   VIII.";
RL   Science 265:2077-2082(1994).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [4]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [5]
RP   FUNCTION.
RX   PubMed=14671320; DOI=10.1073/pnas.2536857100;
RA   Kushner D.B., Lindenbach B.D., Grdzelishvili V.Z., Noueiry A.O., Paul S.M.,
RA   Ahlquist P.;
RT   "Systematic, genome-wide identification of host genes affecting replication
RT   of a positive-strand RNA virus.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:15764-15769(2003).
CC   -!- FUNCTION: Required for replication of brome mosaic virus (BMV), a
CC       positive-strand RNA virus. {ECO:0000269|PubMed:14671320}.
CC   -!- INTERACTION:
CC       P38738; P25366: OCA4; NbExp=4; IntAct=EBI-24355, EBI-22021;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 12500 molecules/cell in log phase SD
CC       medium. {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the OCA5 family. {ECO:0000305}.
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DR   EMBL; U11583; AAB65041.1; -; Genomic_DNA.
DR   EMBL; BK006934; DAA06656.1; -; Genomic_DNA.
DR   PIR; S48939; S48939.
DR   RefSeq; NP_011834.1; NM_001179109.1.
DR   AlphaFoldDB; P38738; -.
DR   BioGRID; 36393; 489.
DR   DIP; DIP-5006N; -.
DR   IntAct; P38738; 9.
DR   MINT; P38738; -.
DR   STRING; 4932.YHL029C; -.
DR   iPTMnet; P38738; -.
DR   MaxQB; P38738; -.
DR   PaxDb; P38738; -.
DR   PRIDE; P38738; -.
DR   EnsemblFungi; YHL029C_mRNA; YHL029C; YHL029C.
DR   GeneID; 856356; -.
DR   KEGG; sce:YHL029C; -.
DR   SGD; S000001021; OCA5.
DR   VEuPathDB; FungiDB:YHL029C; -.
DR   eggNOG; ENOG502QVXN; Eukaryota.
DR   HOGENOM; CLU_028817_0_0_1; -.
DR   InParanoid; P38738; -.
DR   OMA; LGPDIFW; -.
DR   BioCyc; YEAST:G3O-31049-MON; -.
DR   PRO; PR:P38738; -.
DR   Proteomes; UP000002311; Chromosome VIII.
DR   RNAct; P38738; protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..679
FT                   /note="Oxidant-induced cell-cycle arrest protein 5"
FT                   /id="PRO_0000202881"
FT   DOMAIN          50..441
FT                   /note="Rab-GAP TBC"
FT   REGION          135..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..271
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          524..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   679 AA;  77756 MW;  AA2C5434FFDD881A CRC64;
     MHDKKSPMAN SHYLKNLKQQ FRNKNLIETT IHLVKCNDHD SLAFLARTYG VPPQLRHVVW
     PILLKYHPMC ISPNITSNTI SWDPITNDFI LNDPFLKSKA PTDKQDKSDD ENILPYDIES
     IILHDLKKYF HSRSNPAGSS SNANTTNIAT PTPVSSSDAS TISSMEVLSP SLDYEFQIIE
     TLKNAIVKFL LKWSKIFKYE SGLAWIALGL AEWYPIYPYE TMSPFNETHS FYEVEDYVVL
     SGRKHALLST NNGNNGNSNS SSNNTNNNNT NITSGMHNLS INTNTSLHNS PYISHTLSYL
     YKEYPLPFEL RSKLPTKPIF SFSALFERLA LVILHCPDTI LAHKQLKNDS NASSSSKANS
     NFNTNYFPII SGGDLSFQTQ VFFKVFSSIL PELYQPLTEE SSLQPSSSRN SWIYWWLKCS
     GAKALQRQDR GRVWDLLLGW RPKPNMDTIN FFLNYNDKKM DHLYHDTPQC DNEQYWMKDW
     IALYNNDPFW FPDLDSMALG SKKFPYDYSV FKELILRNRY GGTQSKAQKD NTVPSPGSDS
     NDKSELKLPF SSIDPHMQLI FIFIAILQFN EFKLLEFEEA EISEFLNNVP LLTKFDDSSY
     RKLYENTESS ITSLPSSPTT STMASLQSSS NSSAHISNYH MLIEVGNDAK ASHCFDDLLN
     MAGDIWRKWL WRELEESSL