ID   OCAD1_PONAB             Reviewed;         245 AA.
AC   Q5RD48;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=OCIA domain-containing protein 1;
GN   Name=OCIAD1; Synonyms=Asrij {ECO:0000250|UniProtKB:Q9CRD0};
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Maintains stem cell potency (By similarity). Increases STAT3
CC       phosphorylation and controls ERK phosphorylation (By similarity). May
CC       act as a scaffold, increasing STAT3 recruitment onto endosomes (By
CC       similarity). {ECO:0000250|UniProtKB:Q9CRD0}.
CC   -!- SUBUNIT: Interacts with STAT3. {ECO:0000250|UniProtKB:Q9CRD0}.
CC   -!- SUBCELLULAR LOCATION: Endosome {ECO:0000250|UniProtKB:Q9CRD0}.
CC   -!- DOMAIN: The OCIA domain is necessary and sufficient for endosomal
CC       localization. {ECO:0000250|UniProtKB:Q9CRD0}.
CC   -!- MISCELLANEOUS: 'Asrij' stands for 'blood' in Sanskrit as this protein
CC       is strongly expressed in blood vessels.
CC   -!- SIMILARITY: Belongs to the OCIAD1 family. {ECO:0000305}.
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DR   EMBL; CR858070; CAH90309.1; -; mRNA.
DR   RefSeq; NP_001125142.1; NM_001131670.1.
DR   RefSeq; XP_009238215.1; XM_009239940.1.
DR   RefSeq; XP_009238216.1; XM_009239941.1.
DR   RefSeq; XP_009238217.1; XM_009239942.1.
DR   RefSeq; XP_009238218.1; XM_009239943.1.
DR   RefSeq; XP_009238219.1; XM_009239944.1.
DR   RefSeq; XP_009238220.1; XM_009239945.1.
DR   RefSeq; XP_009238221.1; XM_009239946.1.
DR   AlphaFoldDB; Q5RD48; -.
DR   STRING; 9601.ENSPPYP00000016445; -.
DR   Ensembl; ENSPPYT00000041742; ENSPPYP00000027782; ENSPPYG00000014721.
DR   GeneID; 100172028; -.
DR   KEGG; pon:100172028; -.
DR   CTD; 54940; -.
DR   eggNOG; ENOG502RXQR; Eukaryota.
DR   GeneTree; ENSGT00530000063690; -.
DR   HOGENOM; CLU_083038_0_0_1; -.
DR   InParanoid; Q5RD48; -.
DR   OMA; AGKMSYM; -.
DR   OrthoDB; 1322104at2759; -.
DR   TreeFam; TF327106; -.
DR   Proteomes; UP000001595; Chromosome 4.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:2000736; P:regulation of stem cell differentiation; ISS:UniProtKB.
DR   InterPro; IPR040187; OCAD1/2.
DR   InterPro; IPR009764; OCIA_dom.
DR   PANTHER; PTHR13336; PTHR13336; 1.
DR   Pfam; PF07051; OCIA; 1.
PE   2: Evidence at transcript level;
KW   Endosome; Phosphoprotein; Reference proteome.
FT   CHAIN           1..245
FT                   /note="OCIA domain-containing protein 1"
FT                   /id="PRO_0000299383"
FT   DOMAIN          1..112
FT                   /note="OCIA"
FT   REGION          111..142
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          164..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..142
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..212
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        221..245
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         108
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NX40"
FT   MOD_RES         116
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NX40"
FT   MOD_RES         123
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NX40"
FT   MOD_RES         191
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9NX40"
SQ   SEQUENCE   245 AA;  27687 MW;  0D22E52ADBB666AB CRC64;
     MNGRADFREP NAEVPRPIPH IGPDYIPTEE ERRVFAECND ESFWFRSVPL AATSMLITQG
     LISKGILSSH PKYGSIPKLI FACIMGYFAG KLSYVKTCQE KFKKLENSPL GEALRSGQAR
     RSSPPGHYYQ KSKYDSNVSG QSSFVTSPAA DNIEMLPHYE PIPFSSSMNE SAPTGITDHI
     VQGPDPNLEE SPKRKNITYE ELRNKNRESY EVSLTQKTDP SVRPMHERVP KKEVKVNKYG
     DTWDE